Novel carbamoyl type quinine and quinidine based chiral anion exchangers implementing alkyne-azide cycloaddition immobilization chemistry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897209" target="_blank" >RIV/60461373:22310/14:43897209 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0021967314002568" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0021967314002568</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.chroma.2014.02.026" target="_blank" >10.1016/j.chroma.2014.02.026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Novel carbamoyl type quinine and quinidine based chiral anion exchangers implementing alkyne-azide cycloaddition immobilization chemistry

Popis výsledku v původním jazyce

The synthesis and chromatographic evaluation of a series of new Cinchona derived chiral weak anionexchangers is presented. Huisgen Cu(I) mediated alkyne-azide cycloaddition, so-called click chemistry,was used as an immobilization strategy. In this way itwas possible to immobilize about 90% of offeredselector via 1,2,3-triazole linker, which displays a more efficient way of binding the selector to modifiedsilica compared to common radical mediated thiol-ene addition. Problems associated with potentialradical scavenging properties of chiral selectors thereby could be circumvented. The evaluation of thesynthesized chiral stationary phases regarding chromatographic behavior was carried out using polarorganic mode mobile phase composition and a set of representative chiral organic acids. Different loadingdensities revealed an optimum selector density of about 310 mol/g chiral stationary phase with respectto resolution and selectivity. A decrease of performance was observed for higher loadi

Název v anglickém jazyce

Novel carbamoyl type quinine and quinidine based chiral anion exchangers implementing alkyne-azide cycloaddition immobilization chemistry

Popis výsledku anglicky

The synthesis and chromatographic evaluation of a series of new Cinchona derived chiral weak anionexchangers is presented. Huisgen Cu(I) mediated alkyne-azide cycloaddition, so-called click chemistry,was used as an immobilization strategy. In this way itwas possible to immobilize about 90% of offeredselector via 1,2,3-triazole linker, which displays a more efficient way of binding the selector to modifiedsilica compared to common radical mediated thiol-ene addition. Problems associated with potentialradical scavenging properties of chiral selectors thereby could be circumvented. The evaluation of thesynthesized chiral stationary phases regarding chromatographic behavior was carried out using polarorganic mode mobile phase composition and a set of representative chiral organic acids. Different loadingdensities revealed an optimum selector density of about 310 mol/g chiral stationary phase with respectto resolution and selectivity. A decrease of performance was observed for higher loadi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Chromatography A

ISSN

0021-9673

e-ISSN

—

Svazek periodika

1337

Číslo periodika v rámci svazku

18.2.2014

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

85-94

Kód UT WoS článku

000334082200012

EID výsledku v databázi Scopus

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