Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897295" target="_blank" >RIV/60461373:22310/14:43897295 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00213-014-3466-9" target="_blank" >http://dx.doi.org/10.1007/s00213-014-3466-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-014-3466-9" target="_blank" >10.1007/s00213-014-3466-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats

Popis výsledku v původním jazyce

Rationale and objectives Ghrelin, an orexigenic (appetite stimulating) peptide activates binding sites in the ventral tegmental area (a structure linked with the neural reward system) allowing it to participate in reward-seeking behavior. An increasing number of studies over the past few years have demonstrated ghrelin's role in alcohol, cocaine, and nicotine abuse. However, the role of ghrelin, in opioid effects, has rarely been examined. The aim of the present study was to ascertain whether a ghrelinantagonist (JMV2959) was able to inhibit markers of morphine-induced activation of the neural reward system, namely morphine-induced increase of dopamine in the nucleus accumbens and behavioral changes in rats. Methods We used in vivo microdialysis to determine changes of dopamine and its metabolites in the nucleus accumbens shell in rats following morphine (MO, 5, 10 mg/kg s.c.) administration with and without ghrelin antagonist pretreatment (JMV2959, 3, 6 mg/kg i.p., 20 min before MO).

Název v anglickém jazyce

Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats

Popis výsledku anglicky

Rationale and objectives Ghrelin, an orexigenic (appetite stimulating) peptide activates binding sites in the ventral tegmental area (a structure linked with the neural reward system) allowing it to participate in reward-seeking behavior. An increasing number of studies over the past few years have demonstrated ghrelin's role in alcohol, cocaine, and nicotine abuse. However, the role of ghrelin, in opioid effects, has rarely been examined. The aim of the present study was to ascertain whether a ghrelinantagonist (JMV2959) was able to inhibit markers of morphine-induced activation of the neural reward system, namely morphine-induced increase of dopamine in the nucleus accumbens and behavioral changes in rats. Methods We used in vivo microdialysis to determine changes of dopamine and its metabolites in the nucleus accumbens shell in rats following morphine (MO, 5, 10 mg/kg s.c.) administration with and without ghrelin antagonist pretreatment (JMV2959, 3, 6 mg/kg i.p., 20 min before MO).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/LO1215" target="_blank" >LO1215: Pražské vysokoškolské středisko pro ochranu zdraví, bezpečnost potravin a ochranu životního prostředí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychopharmacology

ISSN

1432-2072

e-ISSN

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Svazek periodika

231

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

2899-2908

Kód UT WoS článku

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EID výsledku v databázi Scopus

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