Effect of chain elongation on biological properties of the toxin paralysin beta-alanyl-tyrosine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897357" target="_blank" >RIV/60461373:22310/14:43897357 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/14:43897357 RIV/60461373:22330/14:43897357

Výsledek na webu

<a href="http://dx.doi.org/10.1111/cbdd.12257" target="_blank" >http://dx.doi.org/10.1111/cbdd.12257</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cbdd.12257" target="_blank" >10.1111/cbdd.12257</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of chain elongation on biological properties of the toxin paralysin beta-alanyl-tyrosine

Popis výsledku v původním jazyce

In haemolymph of insect species compounds with remarkable properties for pharmaceutical industry are present. At the first line there were found compounds of low molecular mass, less than 1 kDa. One of such compounds, beta-alanyl-tyrosine (252 Da), was isolated from larval haemolymph of some species of holometabolous insects (e.g. Neobellieria bullata). Its paralytic activity and antimicrobial properties were described until now. In this study we present the effect of elongation of beta-alanyl-tyrosineby repeating of this motive on the biological and physical properties of prepared analogs. For assessment of antimicrobial properties of these new compounds strains of Gram-positive, Gram-negative bacteria and fungi were used, we also followed the haemolytic activity and toxic effect on human cell culture HepG2. On the base of ECD spectroscopy measurement, subsequent molecular modeling and known secondary structure of original beta-alanyl-tyrosine dipeptide the secondary structures of re

Název v anglickém jazyce

Effect of chain elongation on biological properties of the toxin paralysin beta-alanyl-tyrosine

Popis výsledku anglicky

In haemolymph of insect species compounds with remarkable properties for pharmaceutical industry are present. At the first line there were found compounds of low molecular mass, less than 1 kDa. One of such compounds, beta-alanyl-tyrosine (252 Da), was isolated from larval haemolymph of some species of holometabolous insects (e.g. Neobellieria bullata). Its paralytic activity and antimicrobial properties were described until now. In this study we present the effect of elongation of beta-alanyl-tyrosineby repeating of this motive on the biological and physical properties of prepared analogs. For assessment of antimicrobial properties of these new compounds strains of Gram-positive, Gram-negative bacteria and fungi were used, we also followed the haemolytic activity and toxic effect on human cell culture HepG2. On the base of ECD spectroscopy measurement, subsequent molecular modeling and known secondary structure of original beta-alanyl-tyrosine dipeptide the secondary structures of re

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA522%2F09%2F1693" target="_blank" >GA522/09/1693: Úloha antimikrobiálních peptidů v obraně rostlin proti pathogenům</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Biology & Drug Design

ISSN

1747-0285

e-ISSN

—

Svazek periodika

83

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

418-426

Kód UT WoS článku

000332886400005

EID výsledku v databázi Scopus

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