Surface Modification of Biodegradable Poly(L-Lactic Acid) by Argon Plasma: Fibroblasts and Keratinocytes in the Spotlight

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897503" target="_blank" >RIV/60461373:22310/14:43897503 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/14:43897503

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/ppap.201400021/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/ppap.201400021/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ppap.201400021" target="_blank" >10.1002/ppap.201400021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Surface Modification of Biodegradable Poly(L-Lactic Acid) by Argon Plasma: Fibroblasts and Keratinocytes in the Spotlight

Popis výsledku v původním jazyce

Poly(L-lactic acid) [PLLA] is a biodegradable polymer of growing importance for applications in tissue engineering. This work deals with PLLA tuned by Ar plasma treatment (3 W) with the aim to enhance its wettability and cytocompatibility. Changes in surface properties of PLLA caused by plasma treatment were studied in relation to adhesion, proliferation, and metabolic activity of mouse embryonic fibroblasts (NIH 3T3) and human keratinocytes (HaCaT) in vitro. Plasma treatment of PLLA significantly improved adhesion and proliferation of both cell lines when compared to pristine PLLA. Changes in expression of adhesion molecules, talin 1 and vinculin, were also examined. The amount of both proteins in cells cultivated on modified PLLA matrices was lower than in cells grown on pristine PLLA after 24 h of incubation.

Název v anglickém jazyce

Surface Modification of Biodegradable Poly(L-Lactic Acid) by Argon Plasma: Fibroblasts and Keratinocytes in the Spotlight

Popis výsledku anglicky

Poly(L-lactic acid) [PLLA] is a biodegradable polymer of growing importance for applications in tissue engineering. This work deals with PLLA tuned by Ar plasma treatment (3 W) with the aim to enhance its wettability and cytocompatibility. Changes in surface properties of PLLA caused by plasma treatment were studied in relation to adhesion, proliferation, and metabolic activity of mouse embryonic fibroblasts (NIH 3T3) and human keratinocytes (HaCaT) in vitro. Plasma treatment of PLLA significantly improved adhesion and proliferation of both cell lines when compared to pristine PLLA. Changes in expression of adhesion molecules, talin 1 and vinculin, were also examined. The amount of both proteins in cells cultivated on modified PLLA matrices was lower than in cells grown on pristine PLLA after 24 h of incubation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Příprava, modifikace a charakterizace materiálů zářením</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Plasma Processes and Polymers

ISSN

1612-8850

e-ISSN

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Svazek periodika

11

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

1057-1067

Kód UT WoS článku

000344550900007

EID výsledku v databázi Scopus

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