DEGRADATION PRODUCTS OF PHARMACEUTICAL SUBSTANCES IN THE ELECTRIC FIELD

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43898269" target="_blank" >RIV/60461373:22310/14:43898269 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.icct.cz/proceedings/2014/Full_Papers_ICCT_2014.pdf" target="_blank" >http://www.icct.cz/proceedings/2014/Full_Papers_ICCT_2014.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

DEGRADATION PRODUCTS OF PHARMACEUTICAL SUBSTANCES IN THE ELECTRIC FIELD

Popis výsledku v původním jazyce

Pharmaceutical powders are prone to electrostatic charging by interact particles with equipment surface and the surface of other particles. The electrostatic charge of pharmaceutical powder particles affects properties of a raw material and all powder handling procedures, as the generated charge affects character and purity of final dosage form. The effect of electrostatic charge on composition of charged pharmaceutical substances was studied. The experimental charging was performed on samples of selected pharmaceutical substances and the charge was simulated by placing the samples in an electric field. The tested substances are morphinan alkaloids and trospium chloride. The electric fields were generated in two ways - corona discharge (2-10 kV) and byvoltage (15 kV) applied to electrodes attached to a glass horizontal tube. The experimental parameters were chosen to determination relationship between degradation process and the size of applied voltage, the period of charging or the c

Název v anglickém jazyce

DEGRADATION PRODUCTS OF PHARMACEUTICAL SUBSTANCES IN THE ELECTRIC FIELD

Popis výsledku anglicky

Pharmaceutical powders are prone to electrostatic charging by interact particles with equipment surface and the surface of other particles. The electrostatic charge of pharmaceutical powder particles affects properties of a raw material and all powder handling procedures, as the generated charge affects character and purity of final dosage form. The effect of electrostatic charge on composition of charged pharmaceutical substances was studied. The experimental charging was performed on samples of selected pharmaceutical substances and the charge was simulated by placing the samples in an electric field. The tested substances are morphinan alkaloids and trospium chloride. The electric fields were generated in two ways - corona discharge (2-10 kV) and byvoltage (15 kV) applied to electrodes attached to a glass horizontal tube. The experimental parameters were chosen to determination relationship between degradation process and the size of applied voltage, the period of charging or the c

Druh

D - Stať ve sborníku

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 2nd International Conference on Chemical Technology

ISBN

978-80-86238-64-7

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

470-474

Název nakladatele

Ocean Design

Místo vydání

Prague

Místo konání akce

Mikulov, Czech Republic

Datum konání akce

7. 4. 2014

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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