Systematic solvate screening of trospium chloride: discovering hydrates of a long-established pharmaceutical

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43899757" target="_blank" >RIV/60461373:22310/15:43899757 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/15:00451553

Výsledek na webu

<a href="http://dx.doi.org/10.1039/C5CE00744E" target="_blank" >http://dx.doi.org/10.1039/C5CE00744E</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C5CE00744E" target="_blank" >10.1039/C5CE00744E</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Systematic solvate screening of trospium chloride: discovering hydrates of a long-established pharmaceutical

Popis výsledku v původním jazyce

The ability of the antispasmodic agent trospium chloride (TCl) to form solvates was investigated by applying conventional solvate screening methods on 20 solvents. According to the solubility of TCl, different approaches were considered (slow evaporation, slurrying and anti-solvent addition). Five solvates, with the solvents methanol, acetonitrile, propionitrile, N,N-dimethylformamide, nitromethane and dihydrate, were identified and characterized by various analytical techniques. Moreover, a solvate with isopropyl alcohol and TCl sesquihydrate was prepared circumstantially outside the systematic screening. The structures of all the solvates were determined by single crystal X-ray diffraction. The reproducible forms were further characterized by powder X-ray diffraction and desolvation behaviour was observed by thermoanalytical (TGA/DSC) methods. Structural features of novel solvates and of previously described polymorphs and cocrystals of TCl were compared, presented by a tree diagram which classifies the structures according to their molecular packing.

Název v anglickém jazyce

Systematic solvate screening of trospium chloride: discovering hydrates of a long-established pharmaceutical

Popis výsledku anglicky

The ability of the antispasmodic agent trospium chloride (TCl) to form solvates was investigated by applying conventional solvate screening methods on 20 solvents. According to the solubility of TCl, different approaches were considered (slow evaporation, slurrying and anti-solvent addition). Five solvates, with the solvents methanol, acetonitrile, propionitrile, N,N-dimethylformamide, nitromethane and dihydrate, were identified and characterized by various analytical techniques. Moreover, a solvate with isopropyl alcohol and TCl sesquihydrate was prepared circumstantially outside the systematic screening. The structures of all the solvates were determined by single crystal X-ray diffraction. The reproducible forms were further characterized by powder X-ray diffraction and desolvation behaviour was observed by thermoanalytical (TGA/DSC) methods. Structural features of novel solvates and of previously described polymorphs and cocrystals of TCl were compared, presented by a tree diagram which classifies the structures according to their molecular packing.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CrystEngComm

ISSN

1466-8033

e-ISSN

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Svazek periodika

17

Číslo periodika v rámci svazku

25

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

4712-4721

Kód UT WoS článku

000356055000014

EID výsledku v databázi Scopus

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