Thickness and substrate dependences of phase transition, drug release and antibacterial properties of PNIPAm- co -AAc films

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43900163" target="_blank" >RIV/60461373:22310/15:43900163 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/15:43900163

Výsledek na webu

<a href="http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra13972d?page=search" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra13972d?page=search</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c5ra13972d" target="_blank" >10.1039/c5ra13972d</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Thickness and substrate dependences of phase transition, drug release and antibacterial properties of PNIPAm- co -AAc films

Popis výsledku v původním jazyce

Micron and submicron poly(N-isopropylacrylamide)-co-(acrylic acid) (PNIPAm-co-AAc) films were deposited onto silicon and gold substrates by the spin-coating procedure. The in fluence of polymer-substrate interaction and spatial confinement of macromolecular chains in the ultrathin polymer films on lower critical solution temperature (LCST) was investigated under different pH conditions. Shift and broadening of the LCST temperature range was observed from the critical thickness of polymer film. It was also found that the substrate plays a key role in this shift. The observed phenomenon was applied for the temperature-controllable release of a small molecular dopant (crystal violet, CV) from the ultrathin polymer films. Finally, doped ultrathin polymer films were examined for their antibacterial activity by in-contact and drop methods. It was observed that polymer thickness and support substrate can influence both CV release and antibacterial properties. Despite the fact that the concent

Název v anglickém jazyce

Thickness and substrate dependences of phase transition, drug release and antibacterial properties of PNIPAm- co -AAc films

Popis výsledku anglicky

Micron and submicron poly(N-isopropylacrylamide)-co-(acrylic acid) (PNIPAm-co-AAc) films were deposited onto silicon and gold substrates by the spin-coating procedure. The in fluence of polymer-substrate interaction and spatial confinement of macromolecular chains in the ultrathin polymer films on lower critical solution temperature (LCST) was investigated under different pH conditions. Shift and broadening of the LCST temperature range was observed from the critical thickness of polymer film. It was also found that the substrate plays a key role in this shift. The observed phenomenon was applied for the temperature-controllable release of a small molecular dopant (crystal violet, CV) from the ultrathin polymer films. Finally, doped ultrathin polymer films were examined for their antibacterial activity by in-contact and drop methods. It was observed that polymer thickness and support substrate can influence both CV release and antibacterial properties. Despite the fact that the concent

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JJ - Ostatní materiály

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances

ISSN

2046-2069

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

105

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

86825-86831

Kód UT WoS článku

000363179500098

EID výsledku v databázi Scopus

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