Environmentally benign Prins cyclization for the preparation of 2-isobutyl-4-methyl-tetrahydro-2H-pyran-4-ol

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F16%3A43902550" target="_blank" >RIV/60461373:22310/16:43902550 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s11164-016-2511-1" target="_blank" >http://dx.doi.org/10.1007/s11164-016-2511-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11164-016-2511-1" target="_blank" >10.1007/s11164-016-2511-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Environmentally benign Prins cyclization for the preparation of 2-isobutyl-4-methyl-tetrahydro-2H-pyran-4-ol

Popis výsledku v původním jazyce

In this work the green and selective preparation of 2-isobutyl-4-methyl-tetrahydro-2H-pyran-4-ol (also called Florosa or Florol) was performed. The preparation was realized by Prins cyclization of isoprenol and isovaleraldehyde, as a catalyst heteropoly acids (phosphotungstic and phosphomolybdic) were used in homogeneous and also in heterogeneous arrangement. The only solvent necessary for the reaction was water that enables the increase of the selectivity to desired product by hydrolysis of catalyst-carbocation intermediate. The use of heteropolyacids anchored on the MCM-41 also in the water media was even more successful from the point of view of selectivity (96 %) and the catalyst may be reused without loss of activity and selectivity at least four times. The heterogenization of HPAs was performed also in the water.

Název v anglickém jazyce

Environmentally benign Prins cyclization for the preparation of 2-isobutyl-4-methyl-tetrahydro-2H-pyran-4-ol

Popis výsledku anglicky

In this work the green and selective preparation of 2-isobutyl-4-methyl-tetrahydro-2H-pyran-4-ol (also called Florosa or Florol) was performed. The preparation was realized by Prins cyclization of isoprenol and isovaleraldehyde, as a catalyst heteropoly acids (phosphotungstic and phosphomolybdic) were used in homogeneous and also in heterogeneous arrangement. The only solvent necessary for the reaction was water that enables the increase of the selectivity to desired product by hydrolysis of catalyst-carbocation intermediate. The use of heteropolyacids anchored on the MCM-41 also in the water media was even more successful from the point of view of selectivity (96 %) and the catalyst may be reused without loss of activity and selectivity at least four times. The heterogenization of HPAs was performed also in the water.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Research on Chemical Intermediates

ISSN

0922-6168

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

6991-7003

Kód UT WoS článku

000385202400015

EID výsledku v databázi Scopus

—