Enhanced solubility of nanostructured paracetamol

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F17%3A43901727" target="_blank" >RIV/60461373:22310/17:43901727 - isvavai.cz</a>

Výsledek na webu

<a href="http://iopscience.iop.org/article/10.1088/2057-1976/2/5/055007/pdf" target="_blank" >http://iopscience.iop.org/article/10.1088/2057-1976/2/5/055007/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/2057-1976/2/5/055007" target="_blank" >10.1088/2057-1976/2/5/055007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enhanced solubility of nanostructured paracetamol

Popis výsledku v původním jazyce

Athermodynamic top-down approach was used for quantitative prediction of the influence of size and shape of monoclinic paracetamol nanoparticles on their solubility in pure water. A thorough analysis of published experimental data on the bulk paracetamol solubility in water and its melting properties was performed and a temperature dependence of the limiting activity coefficient of paracetamol in the saturated aqueous solution was assessed. Next, the equilibrium condition for the nanostructured paracetamol solubility is derived considering various nanoparticles shapes and the size-dependent interfacial energy at the solid paracetamol/liquid solution interface. Calculation of solubility was performed for spherical particles of radius 1?50 nmas well as for elongated cylindrical particles of various aspect ratios. Size-dependence of interfacial energy gives a maximal solubility for spherical nanoparticles of some critical radius rc. Predicted solubility of cylindrical nanoparticles is greater than for spherical nanoparticles of the same volume due to higher surface-to-volume ratio and higher average interfacial energy corresponding to shape-dependent changes of particle morphology.

Název v anglickém jazyce

Enhanced solubility of nanostructured paracetamol

Popis výsledku anglicky

Athermodynamic top-down approach was used for quantitative prediction of the influence of size and shape of monoclinic paracetamol nanoparticles on their solubility in pure water. A thorough analysis of published experimental data on the bulk paracetamol solubility in water and its melting properties was performed and a temperature dependence of the limiting activity coefficient of paracetamol in the saturated aqueous solution was assessed. Next, the equilibrium condition for the nanostructured paracetamol solubility is derived considering various nanoparticles shapes and the size-dependent interfacial energy at the solid paracetamol/liquid solution interface. Calculation of solubility was performed for spherical particles of radius 1?50 nmas well as for elongated cylindrical particles of various aspect ratios. Size-dependence of interfacial energy gives a maximal solubility for spherical nanoparticles of some critical radius rc. Predicted solubility of cylindrical nanoparticles is greater than for spherical nanoparticles of the same volume due to higher surface-to-volume ratio and higher average interfacial energy corresponding to shape-dependent changes of particle morphology.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Physics and Engineering Express

ISSN

2057-1976

e-ISSN

—

Svazek periodika

2

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

055007

Kód UT WoS článku

000407441500007

EID výsledku v databázi Scopus

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