SERS platform for detection of lipids and disease markers prepared using modification of plasmonic-active gold gratings by lipophilic moieties

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43916455" target="_blank" >RIV/60461373:22310/18:43916455 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/18:10376024

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0925400518304945?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0925400518304945?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.snb.2018.03.016" target="_blank" >10.1016/j.snb.2018.03.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

SERS platform for detection of lipids and disease markers prepared using modification of plasmonic-active gold gratings by lipophilic moieties

Popis výsledku v původním jazyce

New functional SERS platform for effective detection of lipophilic disease markers was proposed and realized. The work was aimed at the achievement of highly-reproducible SERS results obtained in shorter measuring times. The homogeneous plasmon distribution was achieved through the introduction of large area surface plasmon-polariton supported substrate with a good smearing of plasmon intensity along the working substrate area. Homogeneous distribution of targeted lipophilic molecules on the SERS surface was realized through the surface grafting with alkylaryl moieties of various carbon chain lengths via diazonium chemistry. The process of modification was followed and confirmed by XPS and Raman methods. The functionality of created SERS substrates was studied by the contact angle measurement and CVA methods. The possibility of detection of two biomedically significant molecules (squalene and beta-sitosterol) was examined. Dependence of the SERS results on the aliphatic chain lengths was tested in the terms of targeted molecules SERS intensity and reproducibility. The prepared SERS substrates were found to be suitable for sensing of squalene and beta-sitosterol at the biorelevant mu M concentration level.

Název v anglickém jazyce

SERS platform for detection of lipids and disease markers prepared using modification of plasmonic-active gold gratings by lipophilic moieties

Popis výsledku anglicky

New functional SERS platform for effective detection of lipophilic disease markers was proposed and realized. The work was aimed at the achievement of highly-reproducible SERS results obtained in shorter measuring times. The homogeneous plasmon distribution was achieved through the introduction of large area surface plasmon-polariton supported substrate with a good smearing of plasmon intensity along the working substrate area. Homogeneous distribution of targeted lipophilic molecules on the SERS surface was realized through the surface grafting with alkylaryl moieties of various carbon chain lengths via diazonium chemistry. The process of modification was followed and confirmed by XPS and Raman methods. The functionality of created SERS substrates was studied by the contact angle measurement and CVA methods. The possibility of detection of two biomedically significant molecules (squalene and beta-sitosterol) was examined. Dependence of the SERS results on the aliphatic chain lengths was tested in the terms of targeted molecules SERS intensity and reproducibility. The prepared SERS substrates were found to be suitable for sensing of squalene and beta-sitosterol at the biorelevant mu M concentration level.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20501 - Materials engineering

Projekt

<a href="/cs/project/GA15-19485S" target="_blank" >GA15-19485S: Chytré povlaky na bázi polymerů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sensors and Actuators B

ISSN

0925-4005

e-ISSN

—

Svazek periodika

265

Číslo periodika v rámci svazku

JUL 15 2018

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

182-192

Kód UT WoS článku

000430232500022

EID výsledku v databázi Scopus

—