COMPARATIVE STUDY OF BIOLOGICAL RESPONSE OF Ag AND Pd NANOWIRE ARRAYS SUPPORTED ON POLYETHYLENE NAPHTHALATE FOR MEDICAL APPLICATIONS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43916584" target="_blank" >RIV/60461373:22310/18:43916584 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

COMPARATIVE STUDY OF BIOLOGICAL RESPONSE OF Ag AND Pd NANOWIRE ARRAYS SUPPORTED ON POLYETHYLENE NAPHTHALATE FOR MEDICAL APPLICATIONS

Popis výsledku v původním jazyce

In recent days, advancements in nanotechnology ensure everyday applications of nanostructured noble metals, especially silver. Particularly in the medicinal applications, where they profit from their unique antibacterial effects, a serious risk of cytotoxic side-effects may occur. In this work, we studied biological (antibacterial and cytotoxic) response of commonly used silver nanostructures (nanowires, NWs), and compared them with Pd ones, as their possibly safer alternative. Both metal nanostructures were supported on biocompatible polymer - polyethylene naphthalate. The surface of metal/polymer composites was thoroughly characterized by XPS, FIB-SEM and AFM. Thereafter, biological testing of the samples was accomplished. Antibacterial properties of both, Ag and Pd NWs were examined and mutually compared by using Gram-negative bacteria Escherichia coli and Gram-positive Staphylococcus epidermidis, which commonly cause hospital-acquired infections. Finally, the comparative cytotoxic study of both types of composites was carried out using mouse embryonic fibroblasts. Such approach was chosen to determine, whether Pd nanostructures might compete with Ag ones in their medical applications.

Název v anglickém jazyce

COMPARATIVE STUDY OF BIOLOGICAL RESPONSE OF Ag AND Pd NANOWIRE ARRAYS SUPPORTED ON POLYETHYLENE NAPHTHALATE FOR MEDICAL APPLICATIONS

Popis výsledku anglicky

In recent days, advancements in nanotechnology ensure everyday applications of nanostructured noble metals, especially silver. Particularly in the medicinal applications, where they profit from their unique antibacterial effects, a serious risk of cytotoxic side-effects may occur. In this work, we studied biological (antibacterial and cytotoxic) response of commonly used silver nanostructures (nanowires, NWs), and compared them with Pd ones, as their possibly safer alternative. Both metal nanostructures were supported on biocompatible polymer - polyethylene naphthalate. The surface of metal/polymer composites was thoroughly characterized by XPS, FIB-SEM and AFM. Thereafter, biological testing of the samples was accomplished. Antibacterial properties of both, Ag and Pd NWs were examined and mutually compared by using Gram-negative bacteria Escherichia coli and Gram-positive Staphylococcus epidermidis, which commonly cause hospital-acquired infections. Finally, the comparative cytotoxic study of both types of composites was carried out using mouse embryonic fibroblasts. Such approach was chosen to determine, whether Pd nanostructures might compete with Ag ones in their medical applications.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20501 - Materials engineering

Projekt

<a href="/cs/project/GA17-10907S" target="_blank" >GA17-10907S: Dopad nanočástic ušlechtilých kovů na životní prostředí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Nanocon 2017

ISBN

978-80-87294-81-9

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

6

Strana od-do

627-632

Název nakladatele

Tanger s.r.o.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

18. 10. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000452823300103