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Plla honeycomb‐like pattern on fluorinated ethylene propylene as a substrate for fibroblast growth

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F20%3A43920912" target="_blank" >RIV/60461373:22310/20:43920912 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/60461373:22330/20:43920912

  • Výsledek na webu

    <a href="https://doi.org/10.3390/polym12112436" target="_blank" >https://doi.org/10.3390/polym12112436</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/polym12112436" target="_blank" >10.3390/polym12112436</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Plla honeycomb‐like pattern on fluorinated ethylene propylene as a substrate for fibroblast growth

  • Popis výsledku v původním jazyce

    In this study, we present the surface patterning of a biopolymer poly(L‐lactide) (PLLA) for fibroblast growth enhancement. The patterning is based on a self‐organized pore arrangement directly fabricated from a ternary system of a solvent‐nonsolvent biopolymer. We successfully created a porous honeycomb‐like pattern (HCP) on a thermally resistant polymer—fluorinated ethylene propylene (FEP). An important preparation step for HCP is activation of the substrate in Ar plasma discharge. The polymer activation leads to changes in the surface chemistry, which corresponds to an increase in the substrate surface wettability. The aim of this study was to evaluate the influence of the PLLA concentration in solution on the surface morphology, roughness, wettability, and chemistry, and subsequently, also on fibroblast proliferation. We confirmed that the amount of PLLA in solution significantly affects the material surface properties. The pore size of the prepared layers, the surface wettability, and the surface oxygen content increased with an increasing amount of biopolymer in the coating solution. The optimal amount was 1 g of PLLA, which resulted in the highest number of cells after 6 days from seeding; however, all three biopolymer concentrations exhibited significantly better results compared to pristine FEP. The cytocompatibility tests showed that the HCP promoted the attachment of cell filopodia to the underlying substrate and, thus, significantly improved the cell–material interactions. We prepared a honeycomb biodegradable support for enhanced cell growth, so the surface properties of perfluoroethylenepropylene were significantly enhanced.

  • Název v anglickém jazyce

    Plla honeycomb‐like pattern on fluorinated ethylene propylene as a substrate for fibroblast growth

  • Popis výsledku anglicky

    In this study, we present the surface patterning of a biopolymer poly(L‐lactide) (PLLA) for fibroblast growth enhancement. The patterning is based on a self‐organized pore arrangement directly fabricated from a ternary system of a solvent‐nonsolvent biopolymer. We successfully created a porous honeycomb‐like pattern (HCP) on a thermally resistant polymer—fluorinated ethylene propylene (FEP). An important preparation step for HCP is activation of the substrate in Ar plasma discharge. The polymer activation leads to changes in the surface chemistry, which corresponds to an increase in the substrate surface wettability. The aim of this study was to evaluate the influence of the PLLA concentration in solution on the surface morphology, roughness, wettability, and chemistry, and subsequently, also on fibroblast proliferation. We confirmed that the amount of PLLA in solution significantly affects the material surface properties. The pore size of the prepared layers, the surface wettability, and the surface oxygen content increased with an increasing amount of biopolymer in the coating solution. The optimal amount was 1 g of PLLA, which resulted in the highest number of cells after 6 days from seeding; however, all three biopolymer concentrations exhibited significantly better results compared to pristine FEP. The cytocompatibility tests showed that the HCP promoted the attachment of cell filopodia to the underlying substrate and, thus, significantly improved the cell–material interactions. We prepared a honeycomb biodegradable support for enhanced cell growth, so the surface properties of perfluoroethylenepropylene were significantly enhanced.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    20501 - Materials engineering

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/GA19-02495S" target="_blank" >GA19-02495S: Funkcionalizované mikroporézní polymerní struktury typu včelí plástev</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Polymers

  • ISSN

    2073-4360

  • e-ISSN

  • Svazek periodika

    12

  • Číslo periodika v rámci svazku

    11

  • Stát vydavatele periodika

    CH - Švýcarská konfederace

  • Počet stran výsledku

    12

  • Strana od-do

    "2436/1"-12

  • Kód UT WoS článku

    000593883000001

  • EID výsledku v databázi Scopus

    2-s2.0-85093972244