Fully Programmable Collective Behavior of Light-Powered Chemical Microrobotics: pH-Dependent Motion Behavior Switch and Controlled Cancer Cell Destruction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43924101" target="_blank" >RIV/60461373:22310/22:43924101 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/22:43924101 RIV/60461373:22810/22:43924101 RIV/00216305:26620/22:PU145159

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202205062" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202205062</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adfm.202205062" target="_blank" >10.1002/adfm.202205062</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fully Programmable Collective Behavior of Light-Powered Chemical Microrobotics: pH-Dependent Motion Behavior Switch and Controlled Cancer Cell Destruction

Popis výsledku v původním jazyce

The development of fuel-free light-powered multi stimuli-responsive microrobots is becoming a vital field in biomedical research. The challenge is to design biomedical robots with precise motion control and novel functionalities such that one day they will stand alongside medical staff as fully fledged partners in the delivery of advanced non-invasive therapeutic procedures. In this study, a simple one-step etching/polymerization procedure is used to fabricate crystalline metal-organic framework structures surface-coated with a conductive polypyrrole (PPy) layer and then enriched with Methylene Blue sensitizer molecules. Due to the PPy surface charge, the microrobots start to move when exposed to a visible light source, enabling the controllable accumulation of the microrobots at the focal point of the light beam. Furthermore, a self-regulated motion is achieved by the PPy surface charge also providing a pH-dependent switch capable of altering microrobot behavior. In vitro study is conducted to test microrobot efficiency against human cervix carcinoma HeLa cells. It is shown that the micromotors are able to penetrate and successfully destroy the cancer cells. The work provides proof-of-concept for a novel strategy in which such microrobots can be guided by an optical beam, can self-regulate movement toward or away from each other, and can perform therapeutic functions with great efficiency.

Název v anglickém jazyce

Fully Programmable Collective Behavior of Light-Powered Chemical Microrobotics: pH-Dependent Motion Behavior Switch and Controlled Cancer Cell Destruction

Popis výsledku anglicky

The development of fuel-free light-powered multi stimuli-responsive microrobots is becoming a vital field in biomedical research. The challenge is to design biomedical robots with precise motion control and novel functionalities such that one day they will stand alongside medical staff as fully fledged partners in the delivery of advanced non-invasive therapeutic procedures. In this study, a simple one-step etching/polymerization procedure is used to fabricate crystalline metal-organic framework structures surface-coated with a conductive polypyrrole (PPy) layer and then enriched with Methylene Blue sensitizer molecules. Due to the PPy surface charge, the microrobots start to move when exposed to a visible light source, enabling the controllable accumulation of the microrobots at the focal point of the light beam. Furthermore, a self-regulated motion is achieved by the PPy surface charge also providing a pH-dependent switch capable of altering microrobot behavior. In vitro study is conducted to test microrobot efficiency against human cervix carcinoma HeLa cells. It is shown that the micromotors are able to penetrate and successfully destroy the cancer cells. The work provides proof-of-concept for a novel strategy in which such microrobots can be guided by an optical beam, can self-regulate movement toward or away from each other, and can perform therapeutic functions with great efficiency.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Functional Materials

ISSN

1616-301X

e-ISSN

1616-3028

Svazek periodika

32

Číslo periodika v rámci svazku

38

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

nestrankovano

Kód UT WoS článku

000824117000001

EID výsledku v databázi Scopus

2-s2.0-85133974330