Preparation of pH-sensitive surface based on mixed oxides of titanium and iridium for early detection of inflammation around the implant

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F23%3A43926150" target="_blank" >RIV/60461373:22310/23:43926150 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0254058423007344?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0254058423007344?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.matchemphys.2023.128026" target="_blank" >10.1016/j.matchemphys.2023.128026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of pH-sensitive surface based on mixed oxides of titanium and iridium for early detection of inflammation around the implant

Popis výsledku v původním jazyce

The surface of an implant used during operation is a preferred site for the attachment of harmful microorganisms. These subsequently affect the surrounding tissue with their metabolic products, including the tissue´s pH. The possibility of sensing the pH around the implant could be a way of detecting the infection in the early stages. Transition metal oxides can be used for these applications. The most common alloys used for the manufacture of implants are titanium alloys which are characterized by a passive TiO2 surface layer that can be modified. In this work, the Ti-6Al 4V alloy whose surface was nanostructured was used. Iridium particles were subsequently deposited on the prepared surface by various methods to increase the sensitivity to pH change. The potentiostatic mode was chosen as the most suitable method of deposition. Energy dispersive analysis and X-ray photoelectron spectroscopy verified the success of iridium particle deposition. The electrochemical response was measured in a physiological saline solution and monitoring the open circuit potential change proved to be the most appropriate sensing method. After subsequent oxidation process, the prepared surface showed a sensitivity of 64 mV/pH at 37 °C.

Název v anglickém jazyce

Preparation of pH-sensitive surface based on mixed oxides of titanium and iridium for early detection of inflammation around the implant

Popis výsledku anglicky

The surface of an implant used during operation is a preferred site for the attachment of harmful microorganisms. These subsequently affect the surrounding tissue with their metabolic products, including the tissue´s pH. The possibility of sensing the pH around the implant could be a way of detecting the infection in the early stages. Transition metal oxides can be used for these applications. The most common alloys used for the manufacture of implants are titanium alloys which are characterized by a passive TiO2 surface layer that can be modified. In this work, the Ti-6Al 4V alloy whose surface was nanostructured was used. Iridium particles were subsequently deposited on the prepared surface by various methods to increase the sensitivity to pH change. The potentiostatic mode was chosen as the most suitable method of deposition. Energy dispersive analysis and X-ray photoelectron spectroscopy verified the success of iridium particle deposition. The electrochemical response was measured in a physiological saline solution and monitoring the open circuit potential change proved to be the most appropriate sensing method. After subsequent oxidation process, the prepared surface showed a sensitivity of 64 mV/pH at 37 °C.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20501 - Materials engineering

Projekt

<a href="/cs/project/NU20-06-00424" target="_blank" >NU20-06-00424: Implantabilní senzory pro včasnou detekci zánětu a bakteriální kolonizace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials Chemistry and Physics

ISSN

0254-0584

e-ISSN

1879-3312

Svazek periodika

305

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

128026

Kód UT WoS článku

001052974000001

EID výsledku v databázi Scopus

2-s2.0-85161347754