Smart multi stimuli-responsive electrospun nanofibers for on-demand drug release

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F23%3A43926159" target="_blank" >RIV/60461373:22310/23:43926159 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/23:43926159

Výsledek na webu

<a href="https://doi.org/10.1016/j.jcis.2023.05.181" target="_blank" >https://doi.org/10.1016/j.jcis.2023.05.181</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcis.2023.05.181" target="_blank" >10.1016/j.jcis.2023.05.181</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Smart multi stimuli-responsive electrospun nanofibers for on-demand drug release

Popis výsledku v původním jazyce

Here, we report poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAm-co-AAc) microgel-loaded polycaprolactone (PCL) nanofibers as temperature-, pH- and electro-responsive materials. First, the PNIPAm-co-AAc microgels were prepared by precipitation polymerization and then electrospun with PCL. The morphology of the prepared materials, analysed by scanning electron microscopy, showed a narrow nanofiber distribution in the range of 500–800 nm, depending on microgel content. Refractometry measurements, performed at pH 4 and 6.5, as well as in distilled water, indicated the thermo- and pH-responsive behaviour of the nanofibers between 31 and 34 °C. After being thoroughly characterized, the prepared nanofibers were loaded with crystal violet (CV) or gentamicin as model drugs. The application of a pulsed voltage led to a pronounced increase in drug release kinetics, which was also dependent on microgel content. In addition, long-term temperature- and pH-responsive release was demonstrated. Next, the prepared materials displayed switchable antibacterial activity against S. aureus and E. coli. Finally, cell compatibility tests showed that NIH 3T3 fibroblasts spread evenly over the nanofiber surface, confirming that the nanofibers serve as a favourable support for cell growth. Overall, the prepared nanofibers offer switchable drug release and appear to have considerable biomedical potential, particularly in wound healing.

Název v anglickém jazyce

Smart multi stimuli-responsive electrospun nanofibers for on-demand drug release

Popis výsledku anglicky

Here, we report poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAm-co-AAc) microgel-loaded polycaprolactone (PCL) nanofibers as temperature-, pH- and electro-responsive materials. First, the PNIPAm-co-AAc microgels were prepared by precipitation polymerization and then electrospun with PCL. The morphology of the prepared materials, analysed by scanning electron microscopy, showed a narrow nanofiber distribution in the range of 500–800 nm, depending on microgel content. Refractometry measurements, performed at pH 4 and 6.5, as well as in distilled water, indicated the thermo- and pH-responsive behaviour of the nanofibers between 31 and 34 °C. After being thoroughly characterized, the prepared nanofibers were loaded with crystal violet (CV) or gentamicin as model drugs. The application of a pulsed voltage led to a pronounced increase in drug release kinetics, which was also dependent on microgel content. In addition, long-term temperature- and pH-responsive release was demonstrated. Next, the prepared materials displayed switchable antibacterial activity against S. aureus and E. coli. Finally, cell compatibility tests showed that NIH 3T3 fibroblasts spread evenly over the nanofiber surface, confirming that the nanofibers serve as a favourable support for cell growth. Overall, the prepared nanofibers offer switchable drug release and appear to have considerable biomedical potential, particularly in wound healing.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20501 - Materials engineering

Projekt

<a href="/cs/project/GA21-06065S" target="_blank" >GA21-06065S: Nové funkcionalizované senzory založené na plazmonech jako nástroje pro monitorování buněk a pro pokročilé tkáňové inženýrství</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Colloid and Interface Science

ISSN

0021-9797

e-ISSN

1095-7103

Svazek periodika

648

Číslo periodika v rámci svazku

15 October 2023

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

338-347

Kód UT WoS článku

001017578100001

EID výsledku v databázi Scopus

2-s2.0-85161510466