TITANIUM DIOXIDE SOL-GEL COATINGS CONTAINING SILVER AND BIOGLASS PARTICLES AND THEIR ADHESIVE, ANTIBACTERIAL, BIOACTIVE AND CYTOTOXIC PROPERTIES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F25%3A43931512" target="_blank" >RIV/60461373:22310/25:43931512 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/25:43931512

Výsledek na webu

<a href="https://www.ceramics-silikaty.cz/index.php?page=cs_content_doi&id_cislo=224" target="_blank" >https://www.ceramics-silikaty.cz/index.php?page=cs_content_doi&id_cislo=224</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.13168/cs.2025.0014" target="_blank" >10.13168/cs.2025.0014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

TITANIUM DIOXIDE SOL-GEL COATINGS CONTAINING SILVER AND BIOGLASS PARTICLES AND THEIR ADHESIVE, ANTIBACTERIAL, BIOACTIVE AND CYTOTOXIC PROPERTIES

Popis výsledku v původním jazyce

Metal implants used for medical purposes must have physical, chemical and biological properties suitable for their intendeduse. In order to obtain metal biomaterials with optimised properties, their surfaces are modified. The experimental workconsisted of the preparation, characterisation and description of titanium dioxide coatings on commercial titanium. Six typesof coatings were synthesised with a sol-gel method, using a basic titania sol with different concentrations and combinationsof AgNO3 dopants and bioglass. The sols were applied on a mechanically treated titanium substrate by dip-coatingand the coated samples were fired. A basic in vitro bioactivity test was performed under static conditions in a simulatedbody fluid for 21 days to monitor the formation of bonelike hydroxyapatite. The results confirmed the presence of calciumandphosphorus-containing precipitates for coatings containing higher concentrations of bioactive glass in combinationwith silver. The adhesion of the coatings to the substrate was measured by a tape test. The results confirmed the excellentadhesion of all types of the coatings to the substrate. Another measurement examined the antibacterial effects of the coatingsagainst gram-negative Escherichia coli and gram-positive Staphylococcus epidermidis after 4 and 24 hours of interaction.The best results were obtained for coatings containing silver after 24 hours of interaction, which showed a 100 % antibacterialeffect in case of both types of the bacteria. The use of both types of dopants may have affected the cytocompatibilityof the coatings with the host organism and, therefore, also cytotoxicity tests were performed on the L929 and hFOB 1.19 celllines. The results of the indirect tests with hFOB 1.19 suggested that neither of the coatings were toxic. In the contact testswith hFOB 1.19, cells were detected on the selected surfaces of the coatings.

Název v anglickém jazyce

TITANIUM DIOXIDE SOL-GEL COATINGS CONTAINING SILVER AND BIOGLASS PARTICLES AND THEIR ADHESIVE, ANTIBACTERIAL, BIOACTIVE AND CYTOTOXIC PROPERTIES

Popis výsledku anglicky

Metal implants used for medical purposes must have physical, chemical and biological properties suitable for their intendeduse. In order to obtain metal biomaterials with optimised properties, their surfaces are modified. The experimental workconsisted of the preparation, characterisation and description of titanium dioxide coatings on commercial titanium. Six typesof coatings were synthesised with a sol-gel method, using a basic titania sol with different concentrations and combinationsof AgNO3 dopants and bioglass. The sols were applied on a mechanically treated titanium substrate by dip-coatingand the coated samples were fired. A basic in vitro bioactivity test was performed under static conditions in a simulatedbody fluid for 21 days to monitor the formation of bonelike hydroxyapatite. The results confirmed the presence of calciumandphosphorus-containing precipitates for coatings containing higher concentrations of bioactive glass in combinationwith silver. The adhesion of the coatings to the substrate was measured by a tape test. The results confirmed the excellentadhesion of all types of the coatings to the substrate. Another measurement examined the antibacterial effects of the coatingsagainst gram-negative Escherichia coli and gram-positive Staphylococcus epidermidis after 4 and 24 hours of interaction.The best results were obtained for coatings containing silver after 24 hours of interaction, which showed a 100 % antibacterialeffect in case of both types of the bacteria. The use of both types of dopants may have affected the cytocompatibilityof the coatings with the host organism and, therefore, also cytotoxicity tests were performed on the L929 and hFOB 1.19 celllines. The results of the indirect tests with hFOB 1.19 suggested that neither of the coatings were toxic. In the contact testswith hFOB 1.19, cells were detected on the selected surfaces of the coatings.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20506 - Coating and films

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CERAMICS-SILIKATY

ISSN

0862-5468

e-ISSN

1804-5847

Svazek periodika

69

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

298-307

Kód UT WoS článku

001498027200014

EID výsledku v databázi Scopus

2-s2.0-105010439947