New forms of apremilast with halogen derivatives of benzoic acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F25%3A43932779" target="_blank" >RIV/60461373:22310/25:43932779 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2025/ce/d5ce00770d" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/ce/d5ce00770d</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d5ce00770d" target="_blank" >10.1039/d5ce00770d</a>

Jazyk výsledku

angličtina

Název v původním jazyce

New forms of apremilast with halogen derivatives of benzoic acid

Popis výsledku v původním jazyce

Apremilast is a poorly soluble active pharmaceutical ingredient. It is prone to form multicomponent crystals and crystallizes in very similar molecular arrangements. We have crystallized apremilast with derivatives of halogen benzoic acid. Such compounds are known to moderate crystallization processes to different polymorphs of paracetamol. Surprisingly, apremilast structure packing was able to accommodate the o- and m-halogen benzoic acid derivatives in the same structure type as for known structures. On the other hand, crystallization with p-halogen benzoic acid derivatives leads to a cocrystal form with a rare molecular arrangement, which is likely less stable, and hence not preferred in the structures with smaller co-formers. The new forms were characterized by Single Crystal and Powder X-Ray Diffraction, and their stability was studied and compared by Differential Scanning Calorimetry and Thermogravimetric Analysis.

Název v anglickém jazyce

New forms of apremilast with halogen derivatives of benzoic acid

Popis výsledku anglicky

Apremilast is a poorly soluble active pharmaceutical ingredient. It is prone to form multicomponent crystals and crystallizes in very similar molecular arrangements. We have crystallized apremilast with derivatives of halogen benzoic acid. Such compounds are known to moderate crystallization processes to different polymorphs of paracetamol. Surprisingly, apremilast structure packing was able to accommodate the o- and m-halogen benzoic acid derivatives in the same structure type as for known structures. On the other hand, crystallization with p-halogen benzoic acid derivatives leads to a cocrystal form with a rare molecular arrangement, which is likely less stable, and hence not preferred in the structures with smaller co-formers. The new forms were characterized by Single Crystal and Powder X-Ray Diffraction, and their stability was studied and compared by Differential Scanning Calorimetry and Thermogravimetric Analysis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/GX21-05926X" target="_blank" >GX21-05926X: Nanokrystalografie molekulárních krystalů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CRYSTENGCOMM

ISSN

1466-8033

e-ISSN

—

Svazek periodika

27

Číslo periodika v rámci svazku

47

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

7713-7720

Kód UT WoS článku

001611252300001

EID výsledku v databázi Scopus

2-s2.0-105023371698