INTERAKCE OBALOVÝCH GLYKOPROTEINŮ S MATRIXOVÝM PROTEINEM MASON-PFIZEROVA OPIČÍHO VIRU

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F04%3A00012817" target="_blank" >RIV/60461373:22330/04:00012817 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

INTERACTION OF ENVELOPE GLYCOPROTEINS WITH MATRIX PROTEIN OF MASON-PFIZER MONKEY VIRUS

Popis výsledku v původním jazyce

Retroviruses are enveloped viruses, which are released from infected cells by budding through cellular membrane. During this process envelope glycoproteins (Env) are incorporated into the virus particle. Env complex consits of the surface (SU) and the transmembrane (TM) glycoproteins, which are noncovalently associated. The SU glycoprotein is responsible for cellular tropism of the virus, whereas the TM glycoprotein mediates virus-cell membrane fusion during viral entry.Incorporation of glycoproteins tobudding virions is generally believed to be mediated by a specific interaction between cytoplasmic domain of TM and polyprotein precursor Gag, which is precursor of viral structural proteins. Some biochemical evidence for a stable interaction between Pr55Gag and cytoplasmic domain of gp41 in immature HIV-1 particles has been reported and some results suggest that particularly matrix protein (MA), which is localized under lipid envelope of the mature virion, is required for incorporation

Název v anglickém jazyce

INTERACTION OF ENVELOPE GLYCOPROTEINS WITH MATRIX PROTEIN OF MASON-PFIZER MONKEY VIRUS

Popis výsledku anglicky

Retroviruses are enveloped viruses, which are released from infected cells by budding through cellular membrane. During this process envelope glycoproteins (Env) are incorporated into the virus particle. Env complex consits of the surface (SU) and the transmembrane (TM) glycoproteins, which are noncovalently associated. The SU glycoprotein is responsible for cellular tropism of the virus, whereas the TM glycoprotein mediates virus-cell membrane fusion during viral entry.Incorporation of glycoproteins tobudding virions is generally believed to be mediated by a specific interaction between cytoplasmic domain of TM and polyprotein precursor Gag, which is precursor of viral structural proteins. Some biochemical evidence for a stable interaction between Pr55Gag and cytoplasmic domain of gp41 in immature HIV-1 particles has been reported and some results suggest that particularly matrix protein (MA), which is localized under lipid envelope of the mature virion, is required for incorporation

Druh

D - Stať ve sborníku

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/LN00A079" target="_blank" >LN00A079: Centrum integrované genomiky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the XIX. meeting of czech and slovak societies for biochemistry and molecula r biology

ISBN

0232-0061/80-24

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

96

Název nakladatele

Univerzita Palackého

Místo vydání

Olomouc

Místo konání akce

Olomouc

Datum konání akce

3. 9. 2004

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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