Protinádorový a biologický účinek pylové nukleasy z borovice Pinus nigra

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F08%3A00021230" target="_blank" >RIV/60461373:22330/08:00021230 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/08:00321558 RIV/67985904:_____/08:00321558 RIV/00216208:11110/08:1925 RIV/00023736:_____/09:00008251

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antitumor and biological effects of black pine (Pinus nigra) pollen nuclease

Popis výsledku v původním jazyce

The antitumor effect of black pine (Pinus nigra) pollen nuclease (PN) tested in vitro was negligible in comparison with bovine seminal ribonuclease (BS-RNase). However, in the experiments in vivo a significant decrease of the human melanoma tumor size was observed in the mice treated with this nuclease and also with the animal RNases and DNase I. In nude mice injected intratumoraly with PN (10?g/dose) the tumor size decreased from 100% in the control mice to 46% in treated mice whereas in counterparts treated with BS-RNase and DNase I the tumor growth was reduced a little more, however after ten times higher doses (100 and 80?g per dose). Certain aspermatogenic and embryotoxic activity as an expression of side effects of PN and comparative enzymes alsoappeared, but it was lower compared to the effect of bovine seminal ribonuclease. Immunogenicity of PN was significantly weaker in compaison with BS-RNase.The antibodies against black pine nuclease produced in the injected mice did not i

Název v anglickém jazyce

Antitumor and biological effects of black pine (Pinus nigra) pollen nuclease

Popis výsledku anglicky

The antitumor effect of black pine (Pinus nigra) pollen nuclease (PN) tested in vitro was negligible in comparison with bovine seminal ribonuclease (BS-RNase). However, in the experiments in vivo a significant decrease of the human melanoma tumor size was observed in the mice treated with this nuclease and also with the animal RNases and DNase I. In nude mice injected intratumoraly with PN (10?g/dose) the tumor size decreased from 100% in the control mice to 46% in treated mice whereas in counterparts treated with BS-RNase and DNase I the tumor growth was reduced a little more, however after ten times higher doses (100 and 80?g per dose). Certain aspermatogenic and embryotoxic activity as an expression of side effects of PN and comparative enzymes alsoappeared, but it was lower compared to the effect of bovine seminal ribonuclease. Immunogenicity of PN was significantly weaker in compaison with BS-RNase.The antibodies against black pine nuclease produced in the injected mice did not i

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA523%2F04%2F0755" target="_blank" >GA523/04/0755: Biologické a protinádorové účinky oligomerů pankreatické ribonukleázy A</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

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Svazek periodika

55

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000253229100013

EID výsledku v databázi Scopus

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