Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F11%3A43891709" target="_blank" >RIV/60461373:22330/11:43891709 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives

Popis výsledku v původním jazyce

Derivatives of 1,4-dihydro-4-oxoquinoline substituted at 4-pyridone or/and benzene moieties were synthesized (Q1-Q17), and characterized by UV/vis and FT-IR spectroscopy. In dimethylsulfoxide and acetonitrile solvents a significant influence of the substituent's character and position on the quinolone skeleton was observed on the absorption bands in the UVA region (315-400 nm). Electron-withdrawing substituents (nitro, cyano, acetyl or trifluoroacetyl) caused a red shift, resulting in the effective absorption of UVA light. Photoinduced generation of superoxide radical anion and singlet oxygen upon UVA irradiation was followed by EPR spectroscopy using in situ spin trapping technique; 4-hydroxy-2,2,6,6-piperidine (TMP) served for singlet oxygen ((1)O(2)) detection. An efficient generation of superoxide radical anions and singlet oxygen was observed predominantly for nitro-substituted quinolones. The effect of quinolones on proliferation of HL-60 cells was monitored.

Název v anglickém jazyce

Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives

Popis výsledku anglicky

Derivatives of 1,4-dihydro-4-oxoquinoline substituted at 4-pyridone or/and benzene moieties were synthesized (Q1-Q17), and characterized by UV/vis and FT-IR spectroscopy. In dimethylsulfoxide and acetonitrile solvents a significant influence of the substituent's character and position on the quinolone skeleton was observed on the absorption bands in the UVA region (315-400 nm). Electron-withdrawing substituents (nitro, cyano, acetyl or trifluoroacetyl) caused a red shift, resulting in the effective absorption of UVA light. Photoinduced generation of superoxide radical anion and singlet oxygen upon UVA irradiation was followed by EPR spectroscopy using in situ spin trapping technique; 4-hydroxy-2,2,6,6-piperidine (TMP) served for singlet oxygen ((1)O(2)) detection. An efficient generation of superoxide radical anions and singlet oxygen was observed predominantly for nitro-substituted quinolones. The effect of quinolones on proliferation of HL-60 cells was monitored.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Photochemistry and Photobiology A: Chemistry

ISSN

1010-6030

e-ISSN

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Svazek periodika

224

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

123-134

Kód UT WoS článku

000297189600017

EID výsledku v databázi Scopus

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