Design, synthesis and stimuli responsive gelation of novel stigmasterol-amino acid conjugates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F11%3A43892100" target="_blank" >RIV/60461373:22330/11:43892100 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389030:_____/11:00365267

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jcis.2011.05.084" target="_blank" >http://dx.doi.org/10.1016/j.jcis.2011.05.084</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcis.2011.05.084" target="_blank" >10.1016/j.jcis.2011.05.084</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Design, synthesis and stimuli responsive gelation of novel stigmasterol-amino acid conjugates

Popis výsledku v původním jazyce

An efficient synthesis of three novel stigmasterol-amino acid (glycine, L-leucine and L-phenylalanine) conjugates as stimuli responsive gelators is reported. The gelation properties of the prepared compounds were investigated in a variety of organic as well as aqueous solvents. The most striking finding of our investigation was that the hydrochloride salts of the prepared conjugates acted as gelators, whereas the neutral conjugates were either non-gelators or formed only a weak gel in anisole. The hydrochloride salts of stigmasteryl glycinate and L-Ieucinate form gels in n-alcohols (n = 4-10) and in ethane-1,2-diol, and that of stigmasteryl L-phenylalaninate forms gels in aromatic solvents and in tetrachloromethane. These unique properties of the gelators were explored to prepare stimuli responsive, "acid-base" triggered reversible sol-gel transitions. The gelators and their gels were characterized by liquid and solid-state NMR as well as FT-IR.

Název v anglickém jazyce

Design, synthesis and stimuli responsive gelation of novel stigmasterol-amino acid conjugates

Popis výsledku anglicky

An efficient synthesis of three novel stigmasterol-amino acid (glycine, L-leucine and L-phenylalanine) conjugates as stimuli responsive gelators is reported. The gelation properties of the prepared compounds were investigated in a variety of organic as well as aqueous solvents. The most striking finding of our investigation was that the hydrochloride salts of the prepared conjugates acted as gelators, whereas the neutral conjugates were either non-gelators or formed only a weak gel in anisole. The hydrochloride salts of stigmasteryl glycinate and L-Ieucinate form gels in n-alcohols (n = 4-10) and in ethane-1,2-diol, and that of stigmasteryl L-phenylalaninate forms gels in aromatic solvents and in tetrachloromethane. These unique properties of the gelators were explored to prepare stimuli responsive, "acid-base" triggered reversible sol-gel transitions. The gelators and their gels were characterized by liquid and solid-state NMR as well as FT-IR.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Colloid and Interface Science

ISSN

0021-9797

e-ISSN

—

Svazek periodika

361

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

587-593

Kód UT WoS článku

000293038200024

EID výsledku v databázi Scopus

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