Toxicity of benzonitrile herbicides and their bacterial degradation products

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Toxicity of benzonitrile herbicides and their bacterial degradation products

Popis výsledku v původním jazyce

This work is focused to determination of toxicity and genotoxicity of the worldwide commonly used benzonitrile herbicides dichlobenil, chloroxynil, bromoxynil and ioxynil and their metabolites amides and acides. Various systems for the testing of ecotoxicity were used to estimate the toxicity of intermediates of bacterial metabolism in comparison with initial benzonitrile herbicides Sea luminescent bacteria Vibrio fischeri was chosen as the prokaryotic model systems for investigation of the acute ecotoxicity. The eukaryotic model systems were represented by the seeds of Lactuca sativa, var. capitata. We tested also the cytotoxicity effect of herbicides on human hepatocellular carcinoma Hep G2 and human epitheliar fibroblasts HEK 293T. The cytotoxic effect of various concentrations by RTCA DP was compared with the results of standard LDH and MTT cytotoxic tests. Genotoxicity was determinated using the Ames test with bacteria Salmonella typhimurium his- TA98 and TA100. The test with the

Název v anglickém jazyce

Toxicity of benzonitrile herbicides and their bacterial degradation products

Popis výsledku anglicky

This work is focused to determination of toxicity and genotoxicity of the worldwide commonly used benzonitrile herbicides dichlobenil, chloroxynil, bromoxynil and ioxynil and their metabolites amides and acides. Various systems for the testing of ecotoxicity were used to estimate the toxicity of intermediates of bacterial metabolism in comparison with initial benzonitrile herbicides Sea luminescent bacteria Vibrio fischeri was chosen as the prokaryotic model systems for investigation of the acute ecotoxicity. The eukaryotic model systems were represented by the seeds of Lactuca sativa, var. capitata. We tested also the cytotoxicity effect of herbicides on human hepatocellular carcinoma Hep G2 and human epitheliar fibroblasts HEK 293T. The cytotoxic effect of various concentrations by RTCA DP was compared with the results of standard LDH and MTT cytotoxic tests. Genotoxicity was determinated using the Ames test with bacteria Salmonella typhimurium his- TA98 and TA100. The test with the

Druh

D - Stať ve sborníku

CEP obor

DK - Kontaminace a dekontaminace půdy včetně pesticidů

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

5th International Symposium on Biosorption and Bioremediation

ISBN

978-80-7080-825-2

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

81-85

Název nakladatele

VŠCHT Praha

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

24. 6. 2012

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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