Interaction of Mason-Pfizer monkey virus matrix protein with plasma membrane

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F14%3A43897509" target="_blank" >RIV/60461373:22330/14:43897509 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22810/14:43897509

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896817/" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896817/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmicb.2013.00423" target="_blank" >10.3389/fmicb.2013.00423</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interaction of Mason-Pfizer monkey virus matrix protein with plasma membrane

Popis výsledku v původním jazyce

Budding is the final step of the late phase of retroviral life cycle. It begins with the interaction of Gag precursor with plasma membrane (PM) through its N-terminal domain, the matrix protein (MA). However, single genera of Retroviridae family differ in the way how they interact with PM. While in case of Lentiviruses (e.g., human immunodeficiency virus) the structural polyprotein precursor Gag interacts with cellular membrane prior to the assembly, Betaretroviruses [Mason-Pfizer monkey virus (M-PMV)]first assemble their virus-like particles (VLPs) in the pericentriolar region of the infected cell and therefore, already assembled particles interact with the membrane. Although both these types of retroviruses use similar mechanism of the interaction of Gag with the membrane, the difference in the site of assembly leads to some differences in the mechanism of the interaction. Here we describe the interaction of M-PMV MA with PM with emphasis on the structural aspects of the interaction

Název v anglickém jazyce

Interaction of Mason-Pfizer monkey virus matrix protein with plasma membrane

Popis výsledku anglicky

Budding is the final step of the late phase of retroviral life cycle. It begins with the interaction of Gag precursor with plasma membrane (PM) through its N-terminal domain, the matrix protein (MA). However, single genera of Retroviridae family differ in the way how they interact with PM. While in case of Lentiviruses (e.g., human immunodeficiency virus) the structural polyprotein precursor Gag interacts with cellular membrane prior to the assembly, Betaretroviruses [Mason-Pfizer monkey virus (M-PMV)]first assemble their virus-like particles (VLPs) in the pericentriolar region of the infected cell and therefore, already assembled particles interact with the membrane. Although both these types of retroviruses use similar mechanism of the interaction of Gag with the membrane, the difference in the site of assembly leads to some differences in the mechanism of the interaction. Here we describe the interaction of M-PMV MA with PM with emphasis on the structural aspects of the interaction

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/LH12011" target="_blank" >LH12011: Struktura retrovirové částice a intracelulární transport jejích komponent</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Microbiology

ISSN

1664-302X

e-ISSN

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Svazek periodika

4

Číslo periodika v rámci svazku

leden 2014

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

000331693200001

EID výsledku v databázi Scopus

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