Preparation and characterization of lipid nanoparticles containing lipophilic actives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F14%3A43897693" target="_blank" >RIV/60461373:22330/14:43897693 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/14:43897693 RIV/60461373:22340/14:43897693

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Preparation and characterization of lipid nanoparticles containing lipophilic actives

Popis výsledku v původním jazyce

The aim of this study was to prepare two types of colloidal systems, liposomes and lipid nanoparticles, containing commercially available ceramide VI. Ceramides are the main components of the stratum corneum, the physical and mechanical barrier of the skin. Ceramide supplementation is on approach to the treatment of a disrupted skin in diseases such as atopic dermatitis, ichthyosis, psoriasis and others. Different amounts of cermide VI were loaded into the colloidal nanoparticles. High performance thinlayer chromatography was used to confirm the amount of the incorporated ceramide VI. Size and zeta potential of the particles were determined by dynamic light scattering method. The particles were visualized by transmission electron microscopy. Our results suggest that colloidal nanoparticles are suitable drug delivery systems to incorporate ceramide VI. Both, liposomes and lipid nanoparticles, have shown a spherical shpae, an average size below the 100nm and a low polydispersity index.

Název v anglickém jazyce

Preparation and characterization of lipid nanoparticles containing lipophilic actives

Popis výsledku anglicky

The aim of this study was to prepare two types of colloidal systems, liposomes and lipid nanoparticles, containing commercially available ceramide VI. Ceramides are the main components of the stratum corneum, the physical and mechanical barrier of the skin. Ceramide supplementation is on approach to the treatment of a disrupted skin in diseases such as atopic dermatitis, ichthyosis, psoriasis and others. Different amounts of cermide VI were loaded into the colloidal nanoparticles. High performance thinlayer chromatography was used to confirm the amount of the incorporated ceramide VI. Size and zeta potential of the particles were determined by dynamic light scattering method. The particles were visualized by transmission electron microscopy. Our results suggest that colloidal nanoparticles are suitable drug delivery systems to incorporate ceramide VI. Both, liposomes and lipid nanoparticles, have shown a spherical shpae, an average size below the 100nm and a low polydispersity index.

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/GA13-23891S" target="_blank" >GA13-23891S: Modely lipidových membrán - nový nástroj pro studium patofyziologie kožních onemocnění na molekulární úrovni</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 41st International Conference of Slovak Society of Chemical Engineering

ISBN

978-80-89475-13-1

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

817-822

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Tatranské Matliare

Datum konání akce

26. 5. 2014

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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