On the Molecular Pharmacology of Resveratrol on Oxidative Burst Inhibition in Professional Phagocytes
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F14%3A43898328" target="_blank" >RIV/60461373:22330/14:43898328 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1155/2014/706269" target="_blank" >http://dx.doi.org/10.1155/2014/706269</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/706269" target="_blank" >10.1155/2014/706269</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
On the Molecular Pharmacology of Resveratrol on Oxidative Burst Inhibition in Professional Phagocytes
Popis výsledku v původním jazyce
Resveratrol-3,5,4 '-trihydroxystilbene-possesses antioxidant activities in vitro. It dose-dependently inhibited the generation of peroxyl, hydroxyl, peroxides, and lipid peroxidation products in cell free systems. Oxidative burst of whole human blood stimulated with PMA, fMLP, OpZ, and A23187 was inhibited in a concentration-dependent way, indicating suppression of both receptor and nonreceptor activated chemiluminescence by resveratrol. Results from isolated human neutrophils revealed that resveratrolwas active extracellularly as well as intracellularly in inhibiting the generation of reactive oxygen species. Liberation of ATP and analysis of apoptosis showed that in the concentration of 100 mu M, resveratrol did not change the viability and integrity of isolated neutrophils. Western blot analysis documented that resveratrol in concentrations of 10 and 100 mu M significantly decreased PMA-induced phosphorylation of PKC alpha/beta II. Dose-dependent inhibition of nitrite production an
Název v anglickém jazyce
On the Molecular Pharmacology of Resveratrol on Oxidative Burst Inhibition in Professional Phagocytes
Popis výsledku anglicky
Resveratrol-3,5,4 '-trihydroxystilbene-possesses antioxidant activities in vitro. It dose-dependently inhibited the generation of peroxyl, hydroxyl, peroxides, and lipid peroxidation products in cell free systems. Oxidative burst of whole human blood stimulated with PMA, fMLP, OpZ, and A23187 was inhibited in a concentration-dependent way, indicating suppression of both receptor and nonreceptor activated chemiluminescence by resveratrol. Results from isolated human neutrophils revealed that resveratrolwas active extracellularly as well as intracellularly in inhibiting the generation of reactive oxygen species. Liberation of ATP and analysis of apoptosis showed that in the concentration of 100 mu M, resveratrol did not change the viability and integrity of isolated neutrophils. Western blot analysis documented that resveratrol in concentrations of 10 and 100 mu M significantly decreased PMA-induced phosphorylation of PKC alpha/beta II. Dose-dependent inhibition of nitrite production an
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Oxidative Medicine and Cellular Longevity
ISSN
1942-0994
e-ISSN
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Svazek periodika
2014
Číslo periodika v rámci svazku
2014 - Article ID 706269
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
1-9
Kód UT WoS článku
000330936400001
EID výsledku v databázi Scopus
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