Identification of Viagra(R) Counterfeits by Molecular Spectroscopic Methods

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F16%3A43903242" target="_blank" >RIV/60461373:22330/16:43903242 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/16:43903242

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Identification of Viagra(R) Counterfeits by Molecular Spectroscopic Methods

Popis výsledku v původním jazyce

Since the Pfizer's medicine for treating erectile dysfunction Viagra(R) was released in 1998, there were many attempts to produce and sell its counterfeits. Because of the nature of the problem it treats, many people prefere buying it annonymously on the Internet than getting it legaly on receipt. The considerable amount of Viagra(R) counterfeits available on the black market creates a need of analysing them as quickly and reliably as possible. Different analytical methods have been used for the identification of counterfeits, for example X-ray crystallography, nuclear magnetic resonance or various spectroscopic methods. In the present work, Raman spectroscopy was used for the study of the original preparations and counterfeits. There are many favourable aspects of using Raman spectroscopy: the analysis is quick and not destructive and there is no need of sample preparation (spectra of the bulk of tablets can be measured through their coating). Also the future use of chiroptical methods for studying erectile dysfunction medications will be discussed. According to our results, the original and counterfeit preparations can be reliably distinguished according to their spectra. In the spectra of counterfeits, there were missing bands in comparison to the spectra of the original preparations, suggesting that any substance declared to be present was not found in the studied counterfeit. On the other hand, some counterfeits were identified by the presence of additional bands in comparison to the original Viagra(R), so there were substances that the original preparations do not contain.

Název v anglickém jazyce

Identification of Viagra(R) Counterfeits by Molecular Spectroscopic Methods

Popis výsledku anglicky

Since the Pfizer's medicine for treating erectile dysfunction Viagra(R) was released in 1998, there were many attempts to produce and sell its counterfeits. Because of the nature of the problem it treats, many people prefere buying it annonymously on the Internet than getting it legaly on receipt. The considerable amount of Viagra(R) counterfeits available on the black market creates a need of analysing them as quickly and reliably as possible. Different analytical methods have been used for the identification of counterfeits, for example X-ray crystallography, nuclear magnetic resonance or various spectroscopic methods. In the present work, Raman spectroscopy was used for the study of the original preparations and counterfeits. There are many favourable aspects of using Raman spectroscopy: the analysis is quick and not destructive and there is no need of sample preparation (spectra of the bulk of tablets can be measured through their coating). Also the future use of chiroptical methods for studying erectile dysfunction medications will be discussed. According to our results, the original and counterfeit preparations can be reliably distinguished according to their spectra. In the spectra of counterfeits, there were missing bands in comparison to the spectra of the original preparations, suggesting that any substance declared to be present was not found in the studied counterfeit. On the other hand, some counterfeits were identified by the presence of additional bands in comparison to the original Viagra(R), so there were substances that the original preparations do not contain.

Druh

O - Ostatní výsledky

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/VI20152020048" target="_blank" >VI20152020048: Vývoj nových metod a nástrojů pro odhalování a vyšetřování případů padělání léčiv pro zvýšení ochrany společnosti</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů