Combination of non-thermal plasma and subsequent antibiotic treatment for biofilm re-development prevention

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F20%3A43920800" target="_blank" >RIV/60461373:22330/20:43920800 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/20:10413521

Výsledek na webu

<a href="http://file:///C:/Users/kasparkh/AppData/Local/Temp/FoliaCombinationofATBandplasma.pdf" target="_blank" >http://file:///C:/Users/kasparkh/AppData/Local/Temp/FoliaCombinationofATBandplasma.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12223-020-00796-3" target="_blank" >10.1007/s12223-020-00796-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Combination of non-thermal plasma and subsequent antibiotic treatment for biofilm re-development prevention

Popis výsledku v původním jazyce

The influence of non-thermal plasma (NTP) treatment on the prevention of antibiotic resistance of microbial biofilms was studied. Staphylococcus epidermidis and Escherichia coli bacteria and a yeast Candida albicans, grown on the surface of Ti-6Al-4V alloy used in the manufacture of prosthetic implants, were employed. Their biofilms were exposed to NTP produced by DC cometary discharge and subsequently treated with antibiotics commonly used for the treatment of infections caused by them: erythromycin (ERY), polymyxin B (PMB), or amphotericin B (AMB), respectively. All biofilms displayed significant reduction of their metabolic activity after NTP exposure, the most sensitive was S. epidermidis. The subsequent action of antibiotics caused significant decrease in the metabolic activity of S. epidermidis and E. coli, but not C. albicans, although the area covered by biofilm decreased in all cases. The combined effect of NTP with antibiotics was thus proved to be a promising strategy in bacterial pathogen treatment. © 2020, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.

Název v anglickém jazyce

Combination of non-thermal plasma and subsequent antibiotic treatment for biofilm re-development prevention

Popis výsledku anglicky

The influence of non-thermal plasma (NTP) treatment on the prevention of antibiotic resistance of microbial biofilms was studied. Staphylococcus epidermidis and Escherichia coli bacteria and a yeast Candida albicans, grown on the surface of Ti-6Al-4V alloy used in the manufacture of prosthetic implants, were employed. Their biofilms were exposed to NTP produced by DC cometary discharge and subsequently treated with antibiotics commonly used for the treatment of infections caused by them: erythromycin (ERY), polymyxin B (PMB), or amphotericin B (AMB), respectively. All biofilms displayed significant reduction of their metabolic activity after NTP exposure, the most sensitive was S. epidermidis. The subsequent action of antibiotics caused significant decrease in the metabolic activity of S. epidermidis and E. coli, but not C. albicans, although the area covered by biofilm decreased in all cases. The combined effect of NTP with antibiotics was thus proved to be a promising strategy in bacterial pathogen treatment. © 2020, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/GA17-15936S" target="_blank" >GA17-15936S: Interakce nanočástic modifikovaných přírodními látkami s biofilmy patogenních mikroorganismů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Microbiologica

ISSN

0015-5632

e-ISSN

—

Svazek periodika

65

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

863-869

Kód UT WoS článku

000534491800001

EID výsledku v databázi Scopus

2-s2.0-85085548958