The effect of silver nanoparticles on the penetration properties of the skin and quantification of their permeation through skin barrier

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F20%3A43921550" target="_blank" >RIV/60461373:22330/20:43921550 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/20:43921550

Výsledek na webu

<a href="https://doi.org/10.1007/s11051-020-05061-9" target="_blank" >https://doi.org/10.1007/s11051-020-05061-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11051-020-05061-9" target="_blank" >10.1007/s11051-020-05061-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effect of silver nanoparticles on the penetration properties of the skin and quantification of their permeation through skin barrier

Popis výsledku v původním jazyce

Transdermal delivery of drugs represents a non-invasive alternative treatment used not only for skin diseases. As one of the possible penetration enhancing agents, various types of nanoparticles (NPs) could be used. Silver NPs (AgNPs) could be used for some medical purposes considering their antibacterial and antiinflammatory properties. We demonstrate a novel method of quantification of permeated AgNPs, detection of AgNPs dissolving while passing the skin, and examination of interactions between skin and systems with AgNPs. Several AgNPs (exhibiting defined mean diameters of 20, 40, 60, and 100 nm) were added individually to the pure solvents commonly used in pharmaceuticals, namely ethanol, methanol, dimethyl sulfoxide, and demineralized water. AgNP dispersions in different solvents were applied to untreated samples of the skin. Attenuated total reflection technique was used for monitoring the kinetic series of infrared spectra to elucidate the time-dependent changes in the uppermost layer of the skin. The depth profiling spectra series were measured using confocal Raman microspectrometer. All recorded vibrational spectra were evaluated by multivariate statistical methods. A strong influence of AgNP size on the structural changes of the skin surface was evident. The largest changes of the skin structure were caused by the 20-nm and 40-nm AgNPs. Permeation of used AgNPs was studied on vertical Franz diffusion cells with detection of permeated AgNPs by new method based on single-particle inductively coupled plasma mass spectrometry. [Figure not available: see fulltext.] © 2020, Springer Nature B.V.

Název v anglickém jazyce

The effect of silver nanoparticles on the penetration properties of the skin and quantification of their permeation through skin barrier

Popis výsledku anglicky

Transdermal delivery of drugs represents a non-invasive alternative treatment used not only for skin diseases. As one of the possible penetration enhancing agents, various types of nanoparticles (NPs) could be used. Silver NPs (AgNPs) could be used for some medical purposes considering their antibacterial and antiinflammatory properties. We demonstrate a novel method of quantification of permeated AgNPs, detection of AgNPs dissolving while passing the skin, and examination of interactions between skin and systems with AgNPs. Several AgNPs (exhibiting defined mean diameters of 20, 40, 60, and 100 nm) were added individually to the pure solvents commonly used in pharmaceuticals, namely ethanol, methanol, dimethyl sulfoxide, and demineralized water. AgNP dispersions in different solvents were applied to untreated samples of the skin. Attenuated total reflection technique was used for monitoring the kinetic series of infrared spectra to elucidate the time-dependent changes in the uppermost layer of the skin. The depth profiling spectra series were measured using confocal Raman microspectrometer. All recorded vibrational spectra were evaluated by multivariate statistical methods. A strong influence of AgNP size on the structural changes of the skin surface was evident. The largest changes of the skin structure were caused by the 20-nm and 40-nm AgNPs. Permeation of used AgNPs was studied on vertical Franz diffusion cells with detection of permeated AgNPs by new method based on single-particle inductively coupled plasma mass spectrometry. [Figure not available: see fulltext.] © 2020, Springer Nature B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GA17-00291S" target="_blank" >GA17-00291S: Charakterizace anorganických nanočástic pomocí ultrarychlé hmotnostní spektrometrie s indukčně vázaným plazmatem</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Nanoparticle Research

ISSN

1388-0764

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

"332 (2020)"

Kód UT WoS článku

000588306700003

EID výsledku v databázi Scopus

2-s2.0-85094194013