High Prevalence of Likely Passively Acquired Anti-TPO and Anti-GAD Autoantibodies in Common Variable Immunodeficiency
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922209" target="_blank" >RIV/60461373:22330/21:43922209 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/22:10434130 RIV/00064203:_____/22:10434130 RIV/00216208:11110/22:10434130
Výsledek na webu
<a href="https://link-springer-com.ezproxy.vscht.cz/article/10.1007%2Fs10875-021-01171-8" target="_blank" >https://link-springer-com.ezproxy.vscht.cz/article/10.1007%2Fs10875-021-01171-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10875-021-01171-8" target="_blank" >10.1007/s10875-021-01171-8</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
High Prevalence of Likely Passively Acquired Anti-TPO and Anti-GAD Autoantibodies in Common Variable Immunodeficiency
Popis výsledku v původním jazyce
Common variable immunodeficiency disorder (CVID) is one of the most frequent inborn errors of immunity characterized by decreased immunoglobulin production, impaired specific antibody response, and higher susceptibility to infections along with immune system dysregulation and higher prevalence of non-infectious complications [1]. Despite the markedly impaired antibody production, diseases hallmarked by the presence of autoantibodies, such as autoimmune hemolytic anemia (AIHA) or immune thrombocytopenic purpura (ITP), are among the most commonly diagnosed autoimmune complications in CVID patients [2]. The mainstay of CVID management is a regular, long-term immunoglobulin replacement therapy (IRT). Importantly, the immunoglobulin solutions used for IRT were shown to contain various specific antibodies and may even be responsible for IRT-associated adverse events, such as self-limiting acute hemolysis triggered by passivelly transmitted antierythrocyte alloantibodies [3]. Therefore, we initiated a prospective observational trial to determine the prevalence, clinical significance, and origin of the spectrum of autoantibodies in CVID patients on IRT.
Název v anglickém jazyce
High Prevalence of Likely Passively Acquired Anti-TPO and Anti-GAD Autoantibodies in Common Variable Immunodeficiency
Popis výsledku anglicky
Common variable immunodeficiency disorder (CVID) is one of the most frequent inborn errors of immunity characterized by decreased immunoglobulin production, impaired specific antibody response, and higher susceptibility to infections along with immune system dysregulation and higher prevalence of non-infectious complications [1]. Despite the markedly impaired antibody production, diseases hallmarked by the presence of autoantibodies, such as autoimmune hemolytic anemia (AIHA) or immune thrombocytopenic purpura (ITP), are among the most commonly diagnosed autoimmune complications in CVID patients [2]. The mainstay of CVID management is a regular, long-term immunoglobulin replacement therapy (IRT). Importantly, the immunoglobulin solutions used for IRT were shown to contain various specific antibodies and may even be responsible for IRT-associated adverse events, such as self-limiting acute hemolysis triggered by passivelly transmitted antierythrocyte alloantibodies [3]. Therefore, we initiated a prospective observational trial to determine the prevalence, clinical significance, and origin of the spectrum of autoantibodies in CVID patients on IRT.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30102 - Immunology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Clinical Immunology
ISSN
0271-9142
e-ISSN
—
Svazek periodika
42
Číslo periodika v rámci svazku
listopad
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
3
Strana od-do
427-429
Kód UT WoS článku
000718223900001
EID výsledku v databázi Scopus
2-s2.0-85119409581