Ecstasy tablets: Rapid identification and determination of enantiomeric excess of MDMA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922500" target="_blank" >RIV/60461373:22330/21:43922500 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/21:43922500 RIV/00007064:_____/21:N0000022 RIV/00023752:_____/21:43920769

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2468170921000771?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2468170921000771?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.forc.2021.100381" target="_blank" >10.1016/j.forc.2021.100381</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ecstasy tablets: Rapid identification and determination of enantiomeric excess of MDMA

Popis výsledku v původním jazyce

The consumption of psychoactive substances is a worldwide problem and the sheer number of their seizures is alarming. These substances also include the synthetic drug 3,4-methylenedioxy-N-methylamphetamine (MDMA), also known as ecstasy, which is very often abused and widespread around the world. The number of ecstasy tablet seizures testifies to their popularity, especially on the dance music scene. One chiral center can be found in the MDMA molecule and therefore it may occur as two enantiomers, which are characterized by different physiological activity. Therefore, knowledge of the enantiomeric excess in the seized tablets is highly desirable. Within the work, dimensional and weight analysis were performed supported by photographic documentation. In addition, Raman and infrared (IR) spectroscopy were used to verify the content of the active substance in the tablets. Subsequently, the electronic circular dichroism (ECD) was used to construct a calibration curve for the determination of the enantiomeric excess of MDMA in the seized tablets. The obtained results show that most of the seized tablets contained MDMA as a racemate.

Název v anglickém jazyce

Ecstasy tablets: Rapid identification and determination of enantiomeric excess of MDMA

Popis výsledku anglicky

The consumption of psychoactive substances is a worldwide problem and the sheer number of their seizures is alarming. These substances also include the synthetic drug 3,4-methylenedioxy-N-methylamphetamine (MDMA), also known as ecstasy, which is very often abused and widespread around the world. The number of ecstasy tablet seizures testifies to their popularity, especially on the dance music scene. One chiral center can be found in the MDMA molecule and therefore it may occur as two enantiomers, which are characterized by different physiological activity. Therefore, knowledge of the enantiomeric excess in the seized tablets is highly desirable. Within the work, dimensional and weight analysis were performed supported by photographic documentation. In addition, Raman and infrared (IR) spectroscopy were used to verify the content of the active substance in the tablets. Subsequently, the electronic circular dichroism (ECD) was used to construct a calibration curve for the determination of the enantiomeric excess of MDMA in the seized tablets. The obtained results show that most of the seized tablets contained MDMA as a racemate.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/VJ01010043" target="_blank" >VJ01010043: Pharmacrime – forenzní identifikace prohormonů a padělků léčiv</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Forensic Chemistry

ISSN

2468-1709

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

December 2021

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

100381

Kód UT WoS článku

000721143300001

EID výsledku v databázi Scopus

2-s2.0-85119370675