Unexplained post-acute infection syndromesUnexplained post-acute infection syndromes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F22%3A43924715" target="_blank" >RIV/60461373:22330/22:43924715 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41591-022-01810-6" target="_blank" >https://www.nature.com/articles/s41591-022-01810-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41591-022-01810-6" target="_blank" >10.1038/s41591-022-01810-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Unexplained post-acute infection syndromesUnexplained post-acute infection syndromes

Popis výsledku v původním jazyce

SARS-CoV-2 is not unique in its ability to cause post-acute sequelae; certain acute infections have long been associated with an unexplained chronic disability in a minority of patients. These post-acute infection syndromes (PAISs) represent a substantial healthcare burden, but there is a lack of understanding of the underlying mechanisms, representing a significant blind spot in the field of medicine. The relatively similar symptom profiles of individual PAISs, irrespective of the infectious agent, as well as the overlap of clinical features with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggest the potential involvement of a common etiopathogenesis. In this Review, we summarize what is known about unexplained PAISs, provide context for post-acute sequelae of SARS-CoV-2 infection (PASC), and delineate the need for basic biomedical research into the underlying mechanisms behind this group of enigmatic chronic illnesses.

Název v anglickém jazyce

Unexplained post-acute infection syndromesUnexplained post-acute infection syndromes

Popis výsledku anglicky

SARS-CoV-2 is not unique in its ability to cause post-acute sequelae; certain acute infections have long been associated with an unexplained chronic disability in a minority of patients. These post-acute infection syndromes (PAISs) represent a substantial healthcare burden, but there is a lack of understanding of the underlying mechanisms, representing a significant blind spot in the field of medicine. The relatively similar symptom profiles of individual PAISs, irrespective of the infectious agent, as well as the overlap of clinical features with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggest the potential involvement of a common etiopathogenesis. In this Review, we summarize what is known about unexplained PAISs, provide context for post-acute sequelae of SARS-CoV-2 infection (PASC), and delineate the need for basic biomedical research into the underlying mechanisms behind this group of enigmatic chronic illnesses.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30302 - Epidemiology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

NATURE MEDICINE

ISSN

1078-8956

e-ISSN

1546-170X

Svazek periodika

28

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

911-923

Kód UT WoS článku

000797792500015

EID výsledku v databázi Scopus

2-s2.0-85134490774