Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F23%3A43927644" target="_blank" >RIV/60461373:22330/23:43927644 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389030:_____/23:00579197

Výsledek na webu

<a href="https://www.mdpi.com/1420-3049/28/23/7718" target="_blank" >https://www.mdpi.com/1420-3049/28/23/7718</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules28237718" target="_blank" >10.3390/molecules28237718</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents

Popis výsledku v původním jazyce

The results of the most recent investigation of triterpenoid-based antiviral agents namely in the HIV-1 and HSV-1 treatment were reviewed and summarized. Several key historical achievements are included to stress consequences and continuity in this research. Most of the agents studied belong to a series of compounds derived from betulin or betulinic acid, and their synthetic derivative is called bevirimat. A termination of clinical trials of bevirimat in Phase IIb initiated a search for more successful compounds partly derived from bevirimat or designed independently of bevirimat structure. Surprisingly, a majority of bevirimat mimics are derivatives of betulinic acid, while other plant triterpenoids, such as ursolic acid, oleanolic acid, glycyrrhetinic acid, or other miscellaneous triterpenoids, are relatively rarely involved in a search for a novel antiviral agent. Therefore, this review article is divided into three parts based on the leading triterpenoid core structure.

Název v anglickém jazyce

Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents

Popis výsledku anglicky

The results of the most recent investigation of triterpenoid-based antiviral agents namely in the HIV-1 and HSV-1 treatment were reviewed and summarized. Several key historical achievements are included to stress consequences and continuity in this research. Most of the agents studied belong to a series of compounds derived from betulin or betulinic acid, and their synthetic derivative is called bevirimat. A termination of clinical trials of bevirimat in Phase IIb initiated a search for more successful compounds partly derived from bevirimat or designed independently of bevirimat structure. Surprisingly, a majority of bevirimat mimics are derivatives of betulinic acid, while other plant triterpenoids, such as ursolic acid, oleanolic acid, glycyrrhetinic acid, or other miscellaneous triterpenoids, are relatively rarely involved in a search for a novel antiviral agent. Therefore, this review article is divided into three parts based on the leading triterpenoid core structure.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/FV30300" target="_blank" >FV30300: Získávání a využití rostlinných látek s účinky proti stresovým a jiným neurodegenerativním chorobám</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MOLECULES

ISSN

1420-3049

e-ISSN

1420-3049

Svazek periodika

28

Číslo periodika v rámci svazku

23

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

16

Strana od-do

"nestrankovano"

Kód UT WoS článku

001116026100001

EID výsledku v databázi Scopus

2-s2.0-85179370220