Mechanism of staphylococcal resistance to clinically relevant antibiotics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F24%3A43929791" target="_blank" >RIV/60461373:22330/24:43929791 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1368764624001055" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1368764624001055</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.drup.2024.101147" target="_blank" >10.1016/j.drup.2024.101147</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mechanism of staphylococcal resistance to clinically relevant antibiotics

Popis výsledku v původním jazyce

taphylococcus aureus, a notorious pathogen with versatile virulence, poses a significantchallenge to current antibiotic treatments due to its ability to develop resistance mechanismsagainst a variety of clinically relevant antibiotics. In this comprehensive review, we carefullydissect the resistance mechanisms employed by S. aureus against various antibiotics commonlyused in clinical settings. The article navigates through intricate molecular pathways, elucidatingthe mechanisms by which S. aureus evades the therapeutic efficacy of antibiotics, such as β-lactams, vancomycin, daptomycin, linezolid, etc. Each antibiotic is scrutinised for itsmechanism of action, impact on bacterial physiology, and the corresponding resistancestrategies adopted by S. aureus. By synthesising the knowledge surrounding these resistancemechanisms, this review aims to serve as a comprehensive resource that provides a foundationfor the development of innovative therapeutic strategies and alternative treatments for S. aureusinfections. Understanding the evolving landscape of antibiotic resistance is imperative fordevising effective countermeasures in the battle against this formidable pathogen.

Název v anglickém jazyce

Mechanism of staphylococcal resistance to clinically relevant antibiotics

Popis výsledku anglicky

taphylococcus aureus, a notorious pathogen with versatile virulence, poses a significantchallenge to current antibiotic treatments due to its ability to develop resistance mechanismsagainst a variety of clinically relevant antibiotics. In this comprehensive review, we carefullydissect the resistance mechanisms employed by S. aureus against various antibiotics commonlyused in clinical settings. The article navigates through intricate molecular pathways, elucidatingthe mechanisms by which S. aureus evades the therapeutic efficacy of antibiotics, such as β-lactams, vancomycin, daptomycin, linezolid, etc. Each antibiotic is scrutinised for itsmechanism of action, impact on bacterial physiology, and the corresponding resistancestrategies adopted by S. aureus. By synthesising the knowledge surrounding these resistancemechanisms, this review aims to serve as a comprehensive resource that provides a foundationfor the development of innovative therapeutic strategies and alternative treatments for S. aureusinfections. Understanding the evolving landscape of antibiotic resistance is imperative fordevising effective countermeasures in the battle against this formidable pathogen.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

DRUG RESISTANCE UPDATES

ISSN

1368-7646

e-ISSN

1532-2084

Svazek periodika

77

Číslo periodika v rámci svazku

neuveden

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

24

Strana od-do

101147

Kód UT WoS článku

001307764100001

EID výsledku v databázi Scopus

2-s2.0-85202846072