Radioactively labelled porphyrin derivatives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F03%3A00007460" target="_blank" >RIV/60461373:22340/03:00007460 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Radioactively labelled porphyrin derivatives

Popis výsledku v původním jazyce

Radioactive labelling guanidine-bearing tetraphenylporphyrin and Dy-texaphirin with selected radionuclides (166Ho and 90Y) is described. A basic characterisation of studied porphyrin and texaphyrin, including their behaviour in a wide range of pH valuesand data on holmium and yttrium complexation with these compounds was probed using UV-VIS absorption spectrometry. The labelling yield of these macrocyclic molecules depends on the pH of the reaction mixture, metal:ligand ratio and time of incubation. Optimal reaction conditions for formation of porphyrin and texaphyrin radioactive complexes were determined by thin layer chromatography with the detection of B- activity. The ability of porphyrin derivatives to bind anions was examined as well. Our eyperiments were focused on perrhenate ion (ReO4-) because radiopharmaceuticals labelled with isotopes 186Re and 188Re play an important role in therapy of numerous tumour diseases. The possibility of applying ReO4- anion directly for labelling

Název v anglickém jazyce

Radioactively labelled porphyrin derivatives

Popis výsledku anglicky

Radioactive labelling guanidine-bearing tetraphenylporphyrin and Dy-texaphirin with selected radionuclides (166Ho and 90Y) is described. A basic characterisation of studied porphyrin and texaphyrin, including their behaviour in a wide range of pH valuesand data on holmium and yttrium complexation with these compounds was probed using UV-VIS absorption spectrometry. The labelling yield of these macrocyclic molecules depends on the pH of the reaction mixture, metal:ligand ratio and time of incubation. Optimal reaction conditions for formation of porphyrin and texaphyrin radioactive complexes were determined by thin layer chromatography with the detection of B- activity. The ability of porphyrin derivatives to bind anions was examined as well. Our eyperiments were focused on perrhenate ion (ReO4-) because radiopharmaceuticals labelled with isotopes 186Re and 188Re play an important role in therapy of numerous tumour diseases. The possibility of applying ReO4- anion directly for labelling

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Czechoslovak Journal of Physics

ISSN

0011-4626

e-ISSN

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Svazek periodika

53

Číslo periodika v rámci svazku

53

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

755-761

Kód UT WoS článku

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EID výsledku v databázi Scopus

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