Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F03%3A00007465" target="_blank" >RIV/60461373:22340/03:00007465 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid

Popis výsledku v původním jazyce

1-Hydroxyethylidenediphosphonic acid (HEDP), labeled by short-lived radionuclides with the nuclear properties suitable for the therapeutical purposes (186Fe, 188Ho) is similar to the other phosphonates widely applied in the radiopharmaceutical field forthe treatment of palliative bone metastases. One of the important steps for the preparation of compounds of radipharmaceutical interest is the quality control comprehending the radiochemical and chemical purity determination. Chromatographic methods as TLC and HPLC are mostly used for this purpose. Our experiments were focused on the application of capillary electrophoresis with UV detection to the study of rhenium complexation with HEDP. The influence of pH, concentration of the ligand and the reactiontime were determined. Taking in account our previous results, the Re:SnCl2 molar ratio 1.500 (for 0.1 mM Re) was applied to reduce perrhenate to lewer oxidation states which enables the Re-HEDP complexation. Different backround electrolyt

Název v anglickém jazyce

Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid

Popis výsledku anglicky

1-Hydroxyethylidenediphosphonic acid (HEDP), labeled by short-lived radionuclides with the nuclear properties suitable for the therapeutical purposes (186Fe, 188Ho) is similar to the other phosphonates widely applied in the radiopharmaceutical field forthe treatment of palliative bone metastases. One of the important steps for the preparation of compounds of radipharmaceutical interest is the quality control comprehending the radiochemical and chemical purity determination. Chromatographic methods as TLC and HPLC are mostly used for this purpose. Our experiments were focused on the application of capillary electrophoresis with UV detection to the study of rhenium complexation with HEDP. The influence of pH, concentration of the ligand and the reactiontime were determined. Taking in account our previous results, the Re:SnCl2 molar ratio 1.500 (for 0.1 mM Re) was applied to reduce perrhenate to lewer oxidation states which enables the Re-HEDP complexation. Different backround electrolyt

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

—

Projekt

<a href="/cs/project/GA203%2F00%2FD014" target="_blank" >GA203/00/D014: Užití bakteriologických a limnologických testů s mořskými mikroorganizmy pro ekotoxikologický monitoring území kontaminovaných organickými polutanty</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Chromatography A

ISSN

0021-9673

e-ISSN

—

Svazek periodika

990

Číslo periodika v rámci svazku

990

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

317-323

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—