Analýza reakčně-transportních procesů v mikrofluidním systému pro detekci IgG

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F05%3A00015060" target="_blank" >RIV/60461373:22340/05:00015060 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

ANALYSIS OF REACTION-TRANSPORT PHENOMENA IN A MICROFLUIDIC SYSTEM FOR DETECTION OF IGG

Popis výsledku v původním jazyce

The work is focused on mathematical modeling of reaction-transport processes in a microcapillary for immunoassay. A surface biochemical reaction between the immobilized antigen (Protein A) and antibody molecules (IgG) in a solution is studied. The modelis based on reaction-transport equations, the equation of electrostatics and the Navier-Stokes equations. Numerical solutions of the model equations and analytical solutions in special cases are determined. Parametrical studies are also carried out. We have looked for such sets of parameters when the time of the immunoassay between Protein A and IgG can be substantially shortened. The model can be used for design and development of ultra-fast diagnostic systems.

Název v anglickém jazyce

ANALYSIS OF REACTION-TRANSPORT PHENOMENA IN A MICROFLUIDIC SYSTEM FOR DETECTION OF IGG

Popis výsledku anglicky

The work is focused on mathematical modeling of reaction-transport processes in a microcapillary for immunoassay. A surface biochemical reaction between the immobilized antigen (Protein A) and antibody molecules (IgG) in a solution is studied. The modelis based on reaction-transport equations, the equation of electrostatics and the Navier-Stokes equations. Numerical solutions of the model equations and analytical solutions in special cases are determined. Parametrical studies are also carried out. We have looked for such sets of parameters when the time of the immunoassay between Protein A and IgG can be substantially shortened. The model can be used for design and development of ultra-fast diagnostic systems.

Druh

O - Ostatní výsledky

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/GP104%2F03%2FD006" target="_blank" >GP104/03/D006: Studium mikroreaktorů pro bioinženýrské aplikace</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů