Dynamics and transfer of excitation in heart tissue

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F10%3A00023319" target="_blank" >RIV/60461373:22340/10:00023319 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dynamics and transfer of excitation in heart tissue

Popis výsledku v původním jazyce

The cardiac tissue was selected for the purpose of the study of the dynamics and the transfer of excitations. The heart cells are excitable. Their cytoplasmic membranes respond to the depolarization by opening calcium channels and then calcium ions enterthe cells. In reaction to the elevated cytosolic calcium levels the ryanodine receptors in sarcoplasmic reticulum (SR) membrane open. This causes an efflux of calcium ions from the SR into the cytoplasm and raises the Ca levels even more. This mechanismis called Calcium-Induced Calcium Release, commonly abbreviated as CICR. The transfer of excitations between myocytes is provided by the presence of gap junctions--intercellular connections forming aqueous pores. Thus the transfer of Ca ions between cells is possible. The model of myocyte was adopted from the literature and studied using methods of analysis of nonlinear dynamical systems. The cell response to a step change of cytoplasmic membrane voltage was studied. Using a

Název v anglickém jazyce

Dynamics and transfer of excitation in heart tissue

Popis výsledku anglicky

The cardiac tissue was selected for the purpose of the study of the dynamics and the transfer of excitations. The heart cells are excitable. Their cytoplasmic membranes respond to the depolarization by opening calcium channels and then calcium ions enterthe cells. In reaction to the elevated cytosolic calcium levels the ryanodine receptors in sarcoplasmic reticulum (SR) membrane open. This causes an efflux of calcium ions from the SR into the cytoplasm and raises the Ca levels even more. This mechanismis called Calcium-Induced Calcium Release, commonly abbreviated as CICR. The transfer of excitations between myocytes is provided by the presence of gap junctions--intercellular connections forming aqueous pores. Thus the transfer of Ca ions between cells is possible. The model of myocyte was adopted from the literature and studied using methods of analysis of nonlinear dynamical systems. The cell response to a step change of cytoplasmic membrane voltage was studied. Using a

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/GA203%2F09%2F2091" target="_blank" >GA203/09/2091: Funkční dynamika heterogenně-chemických a biochemických reakčních systémů s využitím analýzy reakčních sítí</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

CHISA 2010

ISBN

978-80-02-02210-7

ISSN

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e-ISSN

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Počet stran výsledku

10

Strana od-do

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Název nakladatele

Process Engineering Publisher, Novosad, J.

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

1. 1. 2010

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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