A419C polymorphism of glyoxalase I gene: renal function and histological finding at 12 months after renal transplantation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F10%3A00023496" target="_blank" >RIV/60461373:22340/10:00023496 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A419C polymorphism of glyoxalase I gene: renal function and histological finding at 12 months after renal transplantation

Popis výsledku v původním jazyce

Background and Aims: AGEs (advanced glycation end products) are involved in the pathogenesis of vascular damage and progression of chronic kidney diseases. They are detoxified by the glyoxalase (GLO) system. The aim of the study was to test whether A419Cpolymorphism of GLO I gene is associated with the outcome of kidney transplantation. Methods: A419C polymorphism of the GLO I gene was assessed in 145 renal transplant recipients and its relationship to histological changes in 12 months protocol kidneygraft biopsy and renal function was examined. Results: Genotype frequencies of the studied polymorphism corresponded to the expected frequencies according to Hardy-Weinberg equilibrium. No significant differences among allelic and genotype frequencies among patients with normal histological findings, interstitial fibrosis/tubular atrophy and subclinical rejection and renal parameters were found. However, a trend towards lower levels of serum creatinine and proteinuria was observed in pat

Název v anglickém jazyce

A419C polymorphism of glyoxalase I gene: renal function and histological finding at 12 months after renal transplantation

Popis výsledku anglicky

Background and Aims: AGEs (advanced glycation end products) are involved in the pathogenesis of vascular damage and progression of chronic kidney diseases. They are detoxified by the glyoxalase (GLO) system. The aim of the study was to test whether A419Cpolymorphism of GLO I gene is associated with the outcome of kidney transplantation. Methods: A419C polymorphism of the GLO I gene was assessed in 145 renal transplant recipients and its relationship to histological changes in 12 months protocol kidneygraft biopsy and renal function was examined. Results: Genotype frequencies of the studied polymorphism corresponded to the expected frequencies according to Hardy-Weinberg equilibrium. No significant differences among allelic and genotype frequencies among patients with normal histological findings, interstitial fibrosis/tubular atrophy and subclinical rejection and renal parameters were found. However, a trend towards lower levels of serum creatinine and proteinuria was observed in pat

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Nephrology and Urology

ISSN

2008-4684

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

IR - Íránská islámská republika

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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