Model-based scale-up of vacuum contact drying of pharmaceutical compounds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F11%3A43892161" target="_blank" >RIV/60461373:22340/11:43892161 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ces.2011.06.059" target="_blank" >http://dx.doi.org/10.1016/j.ces.2011.06.059</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ces.2011.06.059" target="_blank" >10.1016/j.ces.2011.06.059</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Model-based scale-up of vacuum contact drying of pharmaceutical compounds

Popis výsledku v původním jazyce

An integrated methodology for the scale-up of vacuum contact drying with intermittent agitation is described in this work. The methodology combines a mathematical model of vacuum contact drying, based on differential transient heat and energy balances, and a small-scale experimental apparatus for model validation and parameter estimation. The validated model was used for the estimation of drying times of six different pharmaceutical compounds at the pilot and manufacturing scale over a range of drying conditions - pressure 15-200 mbar, temperature 45-70 degrees C, solvents: acetone, water, methanol, n-propanol, and isopropyl acetate. The mean difference between predicted and actual drying times for the six compounds was less than 9%, which is considered a significant improvement over current semi-empirical approaches to vacuum contact drying scale-up.

Název v anglickém jazyce

Model-based scale-up of vacuum contact drying of pharmaceutical compounds

Popis výsledku anglicky

An integrated methodology for the scale-up of vacuum contact drying with intermittent agitation is described in this work. The methodology combines a mathematical model of vacuum contact drying, based on differential transient heat and energy balances, and a small-scale experimental apparatus for model validation and parameter estimation. The validated model was used for the estimation of drying times of six different pharmaceutical compounds at the pilot and manufacturing scale over a range of drying conditions - pressure 15-200 mbar, temperature 45-70 degrees C, solvents: acetone, water, methanol, n-propanol, and isopropyl acetate. The mean difference between predicted and actual drying times for the six compounds was less than 9%, which is considered a significant improvement over current semi-empirical approaches to vacuum contact drying scale-up.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

—

Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Engineering Science

ISSN

0009-2509

e-ISSN

—

Svazek periodika

66

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

5045-5054

Kód UT WoS článku

000294205800008

EID výsledku v databázi Scopus

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