Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893432" target="_blank" >RIV/60461373:22340/12:43893432 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16370/12:43871090 RIV/61388980:_____/12:00434359

Výsledek na webu

<a href="http://dx.doi.org/10.3390/molecules171113221" target="_blank" >http://dx.doi.org/10.3390/molecules171113221</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules171113221" target="_blank" >10.3390/molecules171113221</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation

Popis výsledku v původním jazyce

The solubility, absorption and distribution of a drug are involved in the basic aspects of oral bioavailability Solubility is an essential characteristic and influences the efficiency of the drug. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing oral bioavaibility is the technique of nanoparticle preparation, which allows many drugs to thus reach the intended site of action. Candesartan cilexetil and atorvastatin, belonging toclass II of the biopharmaceutical classification system, were chosen as model active pharmaceutical ingredients in this study. Forty samples were prepared either by antisolvent precipitation/solvent evaporation method or by the emulsion/solvent evaporation technique with various commonly used surface-active excipients as nanoparticle stabilizers. All samples were analyzed by means of dynamic light scattering. The particle size of the determined 36 nanoparticle samples was to 574 nm, whe

Název v anglickém jazyce

Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation

Popis výsledku anglicky

The solubility, absorption and distribution of a drug are involved in the basic aspects of oral bioavailability Solubility is an essential characteristic and influences the efficiency of the drug. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing oral bioavaibility is the technique of nanoparticle preparation, which allows many drugs to thus reach the intended site of action. Candesartan cilexetil and atorvastatin, belonging toclass II of the biopharmaceutical classification system, were chosen as model active pharmaceutical ingredients in this study. Forty samples were prepared either by antisolvent precipitation/solvent evaporation method or by the emulsion/solvent evaporation technique with various commonly used surface-active excipients as nanoparticle stabilizers. All samples were analyzed by means of dynamic light scattering. The particle size of the determined 36 nanoparticle samples was to 574 nm, whe

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/GAP304%2F11%2F2246" target="_blank" >GAP304/11/2246: Cílený transport léčiva přes biologické membrány</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecules

ISSN

1420-3049

e-ISSN

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Svazek periodika

17

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

13221-13234

Kód UT WoS článku

000311428400057

EID výsledku v databázi Scopus

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