MATHEMATICAL MODEL OF SIGNAL PROPAGATION IN EPITHELIA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893550" target="_blank" >RIV/60461373:22340/12:43893550 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

MATHEMATICAL MODEL OF SIGNAL PROPAGATION IN EPITHELIA

Popis výsledku v původním jazyce

Mathematical model of signal transmission in epithelial tissue mediated by transmembrane epidermal growth factor receptor has been developed. The signal transmission is mediated by receptors from EGFR family and their ligands. These ligands can be transported by combination of convection and diffusion. Our model takes into account the influence of convection of extracellular medium. Here, we focus on single-layer of epithelial tissue. The developed model was analyzed using asymptotic and numerical methods. We observed nonmonotonous dependence of the propagation velocity on the ligand receptor binding constant under influence of the convective transport. If the signal propagates downstream, the region of high velocities become much broader and spreads over several orders of magnitude of the binding constant. When the convective transport is oriented against the propagating signal, either the velocity of the traveling front wave is slowed down or the traveling front wave can stop or reve

Název v anglickém jazyce

MATHEMATICAL MODEL OF SIGNAL PROPAGATION IN EPITHELIA

Popis výsledku anglicky

Mathematical model of signal transmission in epithelial tissue mediated by transmembrane epidermal growth factor receptor has been developed. The signal transmission is mediated by receptors from EGFR family and their ligands. These ligands can be transported by combination of convection and diffusion. Our model takes into account the influence of convection of extracellular medium. Here, we focus on single-layer of epithelial tissue. The developed model was analyzed using asymptotic and numerical methods. We observed nonmonotonous dependence of the propagation velocity on the ligand receptor binding constant under influence of the convective transport. If the signal propagates downstream, the region of high velocities become much broader and spreads over several orders of magnitude of the binding constant. When the convective transport is oriented against the propagating signal, either the velocity of the traveling front wave is slowed down or the traveling front wave can stop or reve

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/ME10036" target="_blank" >ME10036: Vliv konvektivního toku na šíření chemického signálu v živých tkáních</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

39th International Conference of Slovak Society of Chemical Engineering

ISBN

978-80-89475-04-9

ISSN

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e-ISSN

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Počet stran výsledku

9

Strana od-do

60-68

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Tatranské Matliare, Slovakia

Datum konání akce

21. 5. 2012

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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