Transport properties of silica-coated alginate microparticles for controlled delivery

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Transport properties of silica-coated alginate microparticles for controlled delivery

Popis výsledku v původním jazyce

The aim of this work is to produce silica-coated alginate microparticles with specific controllable shell structure for applications in drug and other chemicals delivery. The microparticles were synthesis in two steps [1, 2]. In the first step, alginategel core were prepared by the drop-on-demand inkjet technology and in the second step the organo-silica shell has been formed by a sol-gel process using alkoxysilane precursors. Using this method, after hydrolysis and polycondensation of precursors, a thin (~1 mým) silica shell precipitates on the alginate cores. Furthermore, pre-synthesised silica nanoparticles can be incorporated into the newly formed silica shell. The specific objective of this work is to systematically investigate the transport properties of this layer by measuring the diffusion rates of a range of proteins with increasing molar weight (14 kDa - 66 kDa). Knowledge of the diffusion rate across the silica shell as function of the protein size is a key for the future a

Název v anglickém jazyce

Transport properties of silica-coated alginate microparticles for controlled delivery

Popis výsledku anglicky

The aim of this work is to produce silica-coated alginate microparticles with specific controllable shell structure for applications in drug and other chemicals delivery. The microparticles were synthesis in two steps [1, 2]. In the first step, alginategel core were prepared by the drop-on-demand inkjet technology and in the second step the organo-silica shell has been formed by a sol-gel process using alkoxysilane precursors. Using this method, after hydrolysis and polycondensation of precursors, a thin (~1 mým) silica shell precipitates on the alginate cores. Furthermore, pre-synthesised silica nanoparticles can be incorporated into the newly formed silica shell. The specific objective of this work is to systematically investigate the transport properties of this layer by measuring the diffusion rates of a range of proteins with increasing molar weight (14 kDa - 66 kDa). Knowledge of the diffusion rate across the silica shell as function of the protein size is a key for the future a

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

39th International Conference of Slovak Society of Chemical Engineering

ISBN

978-80-89475-04-9

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

1031-1035

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Tatranské Matliare

Datum konání akce

21. 5. 2012

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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