Characterization of temperature dependent release rate from liposomes

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Characterization of temperature dependent release rate from liposomes

Popis výsledku v původním jazyce

Liposomes are nanoscaled vesicles. They are able to encapsulate various types of substances because of phospoholipid bilayer that forms their shell. The membrane undergoes phase change at certain temperature that makes bilayer much more permeable than atlower temperatures. This phenomenon can be used for example in medicine for delivery of drugs. Liposomes can be imagined as small reservoir that can contain reactants that will be released from the vesicles after heating. Liposomes were prepared by hydration method using sonication, resp. extrusion as a homogenizing process. The vesicles have diameter of 50 nm to 200 nm depending on preparation conditions. 5(6)-carboxyfluorescein (CF) was chosen as a model substance. Amount of leaked CF was determinedby fluorescence spectroscopy. This work will show release rate studies of liposomes with different composition of their membranes meaning different temperatures of phase-change. The liposomes were made from dipalmitoylphosphatidylcholine

Název v anglickém jazyce

Characterization of temperature dependent release rate from liposomes

Popis výsledku anglicky

Liposomes are nanoscaled vesicles. They are able to encapsulate various types of substances because of phospoholipid bilayer that forms their shell. The membrane undergoes phase change at certain temperature that makes bilayer much more permeable than atlower temperatures. This phenomenon can be used for example in medicine for delivery of drugs. Liposomes can be imagined as small reservoir that can contain reactants that will be released from the vesicles after heating. Liposomes were prepared by hydration method using sonication, resp. extrusion as a homogenizing process. The vesicles have diameter of 50 nm to 200 nm depending on preparation conditions. 5(6)-carboxyfluorescein (CF) was chosen as a model substance. Amount of leaked CF was determinedby fluorescence spectroscopy. This work will show release rate studies of liposomes with different composition of their membranes meaning different temperatures of phase-change. The liposomes were made from dipalmitoylphosphatidylcholine

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

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Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

39th International Conference of Slovak Society of Chemical Engineering

ISBN

978-80-89475-04-9

ISSN

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e-ISSN

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Počet stran výsledku

7

Strana od-do

1209-1215

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Tatranské Matliare

Datum konání akce

21. 5. 2012

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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