Automatic workflow for the classification of local DNA conformations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895100" target="_blank" >RIV/60461373:22340/13:43895100 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/86652036:_____/13:00394810 RIV/60461373:22310/13:43895100

Výsledek na webu

<a href="http://www.biomedcentral.com/content/pdf/1471-2105-14-205.pdf" target="_blank" >http://www.biomedcentral.com/content/pdf/1471-2105-14-205.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1471-2105-14-205" target="_blank" >10.1186/1471-2105-14-205</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Automatic workflow for the classification of local DNA conformations

Popis výsledku v původním jazyce

A growing number of crystal and NMR structures reveals a considerable structural polymorphism of DNA architecture going well beyond the usual image of a double helical molecule. DNA is highly variable with dinucleotide steps exhibiting a substantial flexibility in a sequence-dependent manner. An analysis of the conformational space of the DNA backbone and the enhancement of our understanding of the conformational dependencies in DNA are therefore important for full comprehension of DNA structural polymorphism. A detailed classification of local DNA conformations based on the technique of Fourier averaging was published in our previous work. However, this procedure requires a considerable amount of manual work. To overcome this limitation we developed an automatic classification method consisting of the combination of supervised and unsupervised approaches. A proposed workflow is composed of k-NN method followed by a nonhierarchical single-pass clustering algorithm. We applied this work

Název v anglickém jazyce

Automatic workflow for the classification of local DNA conformations

Popis výsledku anglicky

A growing number of crystal and NMR structures reveals a considerable structural polymorphism of DNA architecture going well beyond the usual image of a double helical molecule. DNA is highly variable with dinucleotide steps exhibiting a substantial flexibility in a sequence-dependent manner. An analysis of the conformational space of the DNA backbone and the enhancement of our understanding of the conformational dependencies in DNA are therefore important for full comprehension of DNA structural polymorphism. A detailed classification of local DNA conformations based on the technique of Fourier averaging was published in our previous work. However, this procedure requires a considerable amount of manual work. To overcome this limitation we developed an automatic classification method consisting of the combination of supervised and unsupervised approaches. A proposed workflow is composed of k-NN method followed by a nonhierarchical single-pass clustering algorithm. We applied this work

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JD - Využití počítačů, robotika a její aplikace

OECD FORD obor

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Projekt

<a href="/cs/project/GAP305%2F12%2F1801" target="_blank" >GAP305/12/1801: Molekulární mechanizmy asociace nového typu transponáz s repetitivními palindromickými sekvencemi</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Bioinformatics

ISSN

1471-2105

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

205

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

000321006500001

EID výsledku v databázi Scopus

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