Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895520" target="_blank" >RIV/60461373:22340/13:43895520 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jcis.2012.11.016" target="_blank" >http://dx.doi.org/10.1016/j.jcis.2012.11.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcis.2012.11.016" target="_blank" >10.1016/j.jcis.2012.11.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes

Popis výsledku v původním jazyce

Composite microparticles consisting of a calcium alginate gel matrix with embedded liposomes made from cholesterol:DPPC (dipalmitoylphosphatidylcholine) mixtures were considered. Factors affecting the encapsulation stability of liposomes during the gel formation by ionic cross-linking ? namely temperature and the cholesterol:DPPC ratio ? were systematically investigated. The liposomes were found to be tolerant to Ca2+ ions during cross-linking of the gel and stable in the hydrogel matrix for extended periods of time when cholesterol was present in the phospholipid bilayer and temperature was kept sufficiently below the phase transition. The temperature-controlled release rate of encapsulated fluorescent dye was quantified. It is shown that a defined quantity of encapsulated substance can be repeatedly released from the embedded liposomes ?on-demand? by short temperature pulses of suitably chosen duration and amplitude. This makes the hydrogel?liposome composites potential candidates fo

Název v anglickém jazyce

Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes

Popis výsledku anglicky

Composite microparticles consisting of a calcium alginate gel matrix with embedded liposomes made from cholesterol:DPPC (dipalmitoylphosphatidylcholine) mixtures were considered. Factors affecting the encapsulation stability of liposomes during the gel formation by ionic cross-linking ? namely temperature and the cholesterol:DPPC ratio ? were systematically investigated. The liposomes were found to be tolerant to Ca2+ ions during cross-linking of the gel and stable in the hydrogel matrix for extended periods of time when cholesterol was present in the phospholipid bilayer and temperature was kept sufficiently below the phase transition. The temperature-controlled release rate of encapsulated fluorescent dye was quantified. It is shown that a defined quantity of encapsulated substance can be repeatedly released from the embedded liposomes ?on-demand? by short temperature pulses of suitably chosen duration and amplitude. This makes the hydrogel?liposome composites potential candidates fo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Colloid and Interface Science

ISSN

0021-9797

e-ISSN

—

Svazek periodika

394

Číslo periodika v rámci svazku

15 March 2013

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

380-385

Kód UT WoS článku

000315325400048

EID výsledku v databázi Scopus

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