Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895520" target="_blank" >RIV/60461373:22340/13:43895520 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.jcis.2012.11.016" target="_blank" >http://dx.doi.org/10.1016/j.jcis.2012.11.016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcis.2012.11.016" target="_blank" >10.1016/j.jcis.2012.11.016</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes
Popis výsledku v původním jazyce
Composite microparticles consisting of a calcium alginate gel matrix with embedded liposomes made from cholesterol:DPPC (dipalmitoylphosphatidylcholine) mixtures were considered. Factors affecting the encapsulation stability of liposomes during the gel formation by ionic cross-linking ? namely temperature and the cholesterol:DPPC ratio ? were systematically investigated. The liposomes were found to be tolerant to Ca2+ ions during cross-linking of the gel and stable in the hydrogel matrix for extended periods of time when cholesterol was present in the phospholipid bilayer and temperature was kept sufficiently below the phase transition. The temperature-controlled release rate of encapsulated fluorescent dye was quantified. It is shown that a defined quantity of encapsulated substance can be repeatedly released from the embedded liposomes ?on-demand? by short temperature pulses of suitably chosen duration and amplitude. This makes the hydrogel?liposome composites potential candidates fo
Název v anglickém jazyce
Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes
Popis výsledku anglicky
Composite microparticles consisting of a calcium alginate gel matrix with embedded liposomes made from cholesterol:DPPC (dipalmitoylphosphatidylcholine) mixtures were considered. Factors affecting the encapsulation stability of liposomes during the gel formation by ionic cross-linking ? namely temperature and the cholesterol:DPPC ratio ? were systematically investigated. The liposomes were found to be tolerant to Ca2+ ions during cross-linking of the gel and stable in the hydrogel matrix for extended periods of time when cholesterol was present in the phospholipid bilayer and temperature was kept sufficiently below the phase transition. The temperature-controlled release rate of encapsulated fluorescent dye was quantified. It is shown that a defined quantity of encapsulated substance can be repeatedly released from the embedded liposomes ?on-demand? by short temperature pulses of suitably chosen duration and amplitude. This makes the hydrogel?liposome composites potential candidates fo
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CI - Průmyslová chemie a chemické inženýrství
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Colloid and Interface Science
ISSN
0021-9797
e-ISSN
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Svazek periodika
394
Číslo periodika v rámci svazku
15 March 2013
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
6
Strana od-do
380-385
Kód UT WoS článku
000315325400048
EID výsledku v databázi Scopus
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