Remote control of reaction and diffusion processes inside microparticles

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Remote control of reaction and diffusion processes inside microparticles

Popis výsledku v původním jazyce

Many scientists deal with a problem of targeted delivery of drugs nowadays. Some of these substances are not very stable, so their synthesis ?in situ? is needed. Control of reaction and release of products requires complex system, using more chemical species and compartmentalization. Our particle is generally a small alginate gel droplet embedding internal compartments and other components. Liposomes play a role of the internal compartments, because permeability of their membrane could be greatly modified by temperature. Alginate beads also contain magnetite nanoparticles so heat can be generated inside the particles by high-frequency magnetic field. Surface of the whole system is covered by several nanometers thin silica layer that provides rigidity and possibility of modification by specific receptors (targeting). Utilizing our system, we were able to remotely control a biochemical reaction between enzyme laccase and its substrate ABTS. The substrate was loaded into thermo-sensitive

Název v anglickém jazyce

Remote control of reaction and diffusion processes inside microparticles

Popis výsledku anglicky

Many scientists deal with a problem of targeted delivery of drugs nowadays. Some of these substances are not very stable, so their synthesis ?in situ? is needed. Control of reaction and release of products requires complex system, using more chemical species and compartmentalization. Our particle is generally a small alginate gel droplet embedding internal compartments and other components. Liposomes play a role of the internal compartments, because permeability of their membrane could be greatly modified by temperature. Alginate beads also contain magnetite nanoparticles so heat can be generated inside the particles by high-frequency magnetic field. Surface of the whole system is covered by several nanometers thin silica layer that provides rigidity and possibility of modification by specific receptors (targeting). Utilizing our system, we were able to remotely control a biochemical reaction between enzyme laccase and its substrate ABTS. The substrate was loaded into thermo-sensitive

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 40th International Conference of Slovak Society of Chemical Engineering

ISBN

978-80-89475-09-4

ISSN

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e-ISSN

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Počet stran výsledku

7

Strana od-do

1056-1062

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Tatranské Matliare

Datum konání akce

27. 5. 2013

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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