Effect of hydrophobic inclusions on polymer swelling kinetics studied by magnetic resonance imaging
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43901964" target="_blank" >RIV/60461373:22340/16:43901964 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.ijpharm.2016.01.023" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2016.01.023</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2016.01.023" target="_blank" >10.1016/j.ijpharm.2016.01.023</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effect of hydrophobic inclusions on polymer swelling kinetics studied by magnetic resonance imaging
Popis výsledku v původním jazyce
The rate of drug release from polymer matrix-based sustained release formulations is often controlled by the thickness of a gel layer that forms upon contact with dissolution medium. The effect of formulation parameters on the kinetics of elementary rate processes that contribute to gel layer formation, such as water ingress, polymer swelling and erosion, is therefore of interest. In the present work, gel layer formation has been investigated by magnetic resonance imaging (MRI), which is a non-destructive method allowing direct visualization of effective water concentration inside the tablet and its surrounding. Using formulations with Levetiracetam as the active ingredient, HPMC as a hydrophilic matrix former and carnauba wax (CW) as a hydrophobic component in the matrix system, the effect of different ratios of these two ingredients on the kinetics of gel formation (MRI) and drug release (USP 4 like dissolution test) has been investigated and interpreted using a mathematical model.
Název v anglickém jazyce
Effect of hydrophobic inclusions on polymer swelling kinetics studied by magnetic resonance imaging
Popis výsledku anglicky
The rate of drug release from polymer matrix-based sustained release formulations is often controlled by the thickness of a gel layer that forms upon contact with dissolution medium. The effect of formulation parameters on the kinetics of elementary rate processes that contribute to gel layer formation, such as water ingress, polymer swelling and erosion, is therefore of interest. In the present work, gel layer formation has been investigated by magnetic resonance imaging (MRI), which is a non-destructive method allowing direct visualization of effective water concentration inside the tablet and its surrounding. Using formulations with Levetiracetam as the active ingredient, HPMC as a hydrophilic matrix former and carnauba wax (CW) as a hydrophobic component in the matrix system, the effect of different ratios of these two ingredients on the kinetics of gel formation (MRI) and drug release (USP 4 like dissolution test) has been investigated and interpreted using a mathematical model.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CI - Průmyslová chemie a chemické inženýrství
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA13-09914S" target="_blank" >GA13-09914S: Studium difuzních procesů v porézních látkách s proměnnou propustností</a><br>
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Pharmaceutics
ISSN
0378-5173
e-ISSN
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Svazek periodika
500
Číslo periodika v rámci svazku
1-2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
136-143
Kód UT WoS článku
000370049900014
EID výsledku v databázi Scopus
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