Computer simulation of pharmaceutical tablet disintegration

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F17%3A43914034" target="_blank" >RIV/60461373:22340/17:43914034 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Computer simulation of pharmaceutical tablet disintegration

Popis výsledku v původním jazyce

The medicament can be administered to a patient in different forms, for example, as liquid syrup, semisolid ointment or solid capsules or tablets which are the most common form. Tablet usually contains a drug substance (API) and a variety of excipients (inactive ingredients) with different purpose, for example, to improve tablet stability, to modify its flavor or color, or to act as binders holding tablet together or fillers forming the necessary tablet volume. Disintegrants are excipients essential for tablet usability because they cause the rupture of the tablet and therefore promote API dissolution and its release from the tablet. The objective of this work is to create a mathematical model of the tablet composed from two constituents: excipient (disintegrant) and API. The purpose of this model is to simulate tablet disintegration and dissolution and to investigate the influence of the tablet microstructure (distribution of API and excipient within the tablet, amount of API in the tablet, size of API clusters and API/excipient dissolution rate ratio) on tablet disintegration considering percolation theory thresholds.

Název v anglickém jazyce

Computer simulation of pharmaceutical tablet disintegration

Popis výsledku anglicky

The medicament can be administered to a patient in different forms, for example, as liquid syrup, semisolid ointment or solid capsules or tablets which are the most common form. Tablet usually contains a drug substance (API) and a variety of excipients (inactive ingredients) with different purpose, for example, to improve tablet stability, to modify its flavor or color, or to act as binders holding tablet together or fillers forming the necessary tablet volume. Disintegrants are excipients essential for tablet usability because they cause the rupture of the tablet and therefore promote API dissolution and its release from the tablet. The objective of this work is to create a mathematical model of the tablet composed from two constituents: excipient (disintegrant) and API. The purpose of this model is to simulate tablet disintegration and dissolution and to investigate the influence of the tablet microstructure (distribution of API and excipient within the tablet, amount of API in the tablet, size of API clusters and API/excipient dissolution rate ratio) on tablet disintegration considering percolation theory thresholds.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

<a href="/cs/project/GA15-05534S" target="_blank" >GA15-05534S: Studie vztahu mezi strukturou a vlastnostmi složitých granulárních systémů a dynamiky jejich lámání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

PROCEEDINGS 44th International Conference of the Slovak Society of Chemical Engineering

ISBN

978-80-89597-58-1

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

10

Strana od-do

867-876

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Demänovská dolina

Datum konání akce

22. 5. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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