Optimization of excipients for pharmaceutical dosage forms prepared by FDM 3D-printing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F17%3A43914054" target="_blank" >RIV/60461373:22340/17:43914054 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Optimization of excipients for pharmaceutical dosage forms prepared by FDM 3D-printing

Popis výsledku v původním jazyce

3D printing of tablet-shaped dosage forms is a novel approach in pharmaceutical formulation, since 2015 it has its first commercial application. This method presents new advantages in the area of personalized dosing - each printed product can be tailored to meet the needs of a specific patient. Fused Deposition Modeling, a commercially available 3D printing technology, employed in the presented work, utilizes solid filaments made of thermoplastic materials as feed. The filaments were produced by mixing biodegradable pharmaceutical polymers, additives (plasticizers, anticaking agents or disintegrants) and defined contents of model drugs, and subsequently processing the powder-based mixtures by Hot-melt extrusion. The main challenge of this process, as was also reported in relevant contemporary literature, is to achieve printability of the produced filaments ? their mechanical properties have meet the requirements of the 3D-printing technology. Therefore, this work focuses on the effects of various excipients on the overall printability of the mixture. Furthermore, pharmaceutically relevant characteristics, such as achieved drug content, structure and inner porosity of the filaments were analyzed and will be discussed.

Název v anglickém jazyce

Optimization of excipients for pharmaceutical dosage forms prepared by FDM 3D-printing

Popis výsledku anglicky

3D printing of tablet-shaped dosage forms is a novel approach in pharmaceutical formulation, since 2015 it has its first commercial application. This method presents new advantages in the area of personalized dosing - each printed product can be tailored to meet the needs of a specific patient. Fused Deposition Modeling, a commercially available 3D printing technology, employed in the presented work, utilizes solid filaments made of thermoplastic materials as feed. The filaments were produced by mixing biodegradable pharmaceutical polymers, additives (plasticizers, anticaking agents or disintegrants) and defined contents of model drugs, and subsequently processing the powder-based mixtures by Hot-melt extrusion. The main challenge of this process, as was also reported in relevant contemporary literature, is to achieve printability of the produced filaments ? their mechanical properties have meet the requirements of the 3D-printing technology. Therefore, this work focuses on the effects of various excipients on the overall printability of the mixture. Furthermore, pharmaceutically relevant characteristics, such as achieved drug content, structure and inner porosity of the filaments were analyzed and will be discussed.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

<a href="/cs/project/GJ17-21696Y" target="_blank" >GJ17-21696Y: Studium tvorby obrazců kapek dekanolu vyvolané odpařováním</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

PROCEEDINGS 44th International Conference of the Slovak Society of Chemical Engineering

ISBN

978-80-89597-58-1

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

1

Strana od-do

661

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Demänovská dolina

Datum konání akce

22. 5. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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