Mesoporous silica nanoparticles scale-up study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F17%3A43914060" target="_blank" >RIV/60461373:22340/17:43914060 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Mesoporous silica nanoparticles scale-up study

Popis výsledku v původním jazyce

The goal of this work was to conduct scale-up of a synthesis method for producing hollow mesoporous silica nanoparticles in order to increase the particle production yield from tens of miligrams to grams. The original emulsion based synthesis was utilised for the production of 400 nm solid-core or 650 nm hollow-core mesoporous silica nanoparticles using tetraethyl orthosilicate (TEOS) as a silica source and cetrimmonium bromide (CTAB) as a surfactant. Two different scale-up strategies were explored, volumetric based scale-up and concentration based scale-up. The first strategy focused on increasing the overall volume (from 40 ml to 1650 ml), while keeping the reagent concentrations unchanged, fine-tuning only the stirring conditions and the reaction vessel geometry. The concentration based scale up was conducted using a smaller, constant volume (160 ml) and the concentrations of the primary reagents (TEOS and CTAB) were being increased at various ratios up to four-fold in an attempt to increase the overall yield per unit volume of the synthesis mixture. Both scale-up strategies provided satisfactory results. Using the volume based strategy it was possible to synthesise particles of almost identical shape, size and porosity as with the original synthesis when the appropriate stirring conditions were set. Both solid-core and hollow-core particles were prepared at 1650 ml scale yielding approximately 4-5 g of particles per batch. With improper stirring settings at this scale, the synthesis still yielded particles, but the particles suffered from significant aggregation issues and in some cases their morphology changed as well. In the concentration scale-up experiments, with increasing reagent concentrations, new morphologies of particles were obtained, however, the particles were forming larger aggregates. Upon increasing the TEOS and CTAB concentrations even higher (by three to four fold) the aggregation disappeared and 300 - 400 nm solid core mesoporous particles were obtained. It was also observed that increasing only the TEOS concentration without equally increasing the CTAB concentration results in a significant decrease in the synthesis yield. On the other hand, when the reagent ratios are kept, the synthesis yield remains unchanged regardless of the synthesis volume or stirring conditions.

Název v anglickém jazyce

Mesoporous silica nanoparticles scale-up study

Popis výsledku anglicky

The goal of this work was to conduct scale-up of a synthesis method for producing hollow mesoporous silica nanoparticles in order to increase the particle production yield from tens of miligrams to grams. The original emulsion based synthesis was utilised for the production of 400 nm solid-core or 650 nm hollow-core mesoporous silica nanoparticles using tetraethyl orthosilicate (TEOS) as a silica source and cetrimmonium bromide (CTAB) as a surfactant. Two different scale-up strategies were explored, volumetric based scale-up and concentration based scale-up. The first strategy focused on increasing the overall volume (from 40 ml to 1650 ml), while keeping the reagent concentrations unchanged, fine-tuning only the stirring conditions and the reaction vessel geometry. The concentration based scale up was conducted using a smaller, constant volume (160 ml) and the concentrations of the primary reagents (TEOS and CTAB) were being increased at various ratios up to four-fold in an attempt to increase the overall yield per unit volume of the synthesis mixture. Both scale-up strategies provided satisfactory results. Using the volume based strategy it was possible to synthesise particles of almost identical shape, size and porosity as with the original synthesis when the appropriate stirring conditions were set. Both solid-core and hollow-core particles were prepared at 1650 ml scale yielding approximately 4-5 g of particles per batch. With improper stirring settings at this scale, the synthesis still yielded particles, but the particles suffered from significant aggregation issues and in some cases their morphology changed as well. In the concentration scale-up experiments, with increasing reagent concentrations, new morphologies of particles were obtained, however, the particles were forming larger aggregates. Upon increasing the TEOS and CTAB concentrations even higher (by three to four fold) the aggregation disappeared and 300 - 400 nm solid core mesoporous particles were obtained. It was also observed that increasing only the TEOS concentration without equally increasing the CTAB concentration results in a significant decrease in the synthesis yield. On the other hand, when the reagent ratios are kept, the synthesis yield remains unchanged regardless of the synthesis volume or stirring conditions.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

<a href="/cs/project/GA15-06479S" target="_blank" >GA15-06479S: Příprava nových polymerních membrán s kontrolovaně zabudovanými aditivy pro efektivní separaci CO2 ze směsí plynů a jejich charakterizace</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

PROCEEDINGS 44th International Conference of the Slovak Society of Chemical Engineering

ISBN

978-80-89597-58-1

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

9

Strana od-do

640-648

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Demänovská dolina

Datum konání akce

22. 5. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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